Evidence map›Paper›PMID 28197555›Full record

ArticleeNeuro

Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation.

Yili Zhang, Paul Smolen, Douglas A Baxter, John H Byrne

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. The Right Time for a Synapse to Change: Windows and Mechanisms of Multiday Training Trials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  9. ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yili ZhangDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77030.ORCID 0000-0002-2591-1324
Paul SmolenDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77030.
Douglas A BaxterDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77030.
John H ByrneDepartment of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, TX 77030.ORCID 0000-0001-7947-5890
The University of Texas Health Science Center · US

Funding

NEURAL CONTROL OF BEHAVIORR01NS019895 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H · 1985 to 2022
$8.3M
Modeling Gene Regulation Essential for Long-Term PlasticityR01NS073974 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H · 2011 to 2015
$1.5M
NINDS NIH HHS R01 NS019895NINDS NIH HHS R01 NS073974
6 · The paper itself

Abstract

The MAPK isoforms ERK and p38 MAPK are believed to play opposing roles in long-term synaptic facilitation (LTF) induced by serotonin (5-HT) in

Indexed as

AnimalsAplysiaCells, CulturedComputer SimulationExtracellular Signal-Regulated MAP KinasesFluorescent Antibody TechniqueLong-Term PotentiationMitogen-Activated Protein Kinase KinasesModels, Neurologicalp38 Mitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsSensory Receptor CellsSerotoninTime FactorsExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein Kinase Kinasesp38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsSerotoninbiphasic regulationcomputational modelERKLTFp38 MAPKspaced stimulation

Identifiers

PMID28197555
PMCPMC5307297
OpenAlexW2580666828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.