Evidence map›Paper›PMID 28197552›Full record

ArticleeNeuro

Altered Channel Conductance States and Gating of GABA

Ciria C Hernandez, Weijing Kong, Ningning Hu, Yujia Zhang, Wangzhen Shen, Laurel Jackson, Xiaoyan Liu, Yuwu Jiang, Robert L Macdonald

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  4. Review
  5. Understanding paralogous epilepsy-associated GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. GABAJournal of neurochemistry · 2024
    Review
  7. Review
  8. Article
  9. Biomolecules · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Phenotypic Spectrum and Prognosis of Epilepsy Patients WithFrontiers in molecular neuroscience · 2022
    Article
  14. Review
  15. Dravet syndrome-associated mutations inBrain communications · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Pathogenic Variants inInternational journal of molecular sciences · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ciria C HernandezDepartment of Neurology, Vanderbilt University Medical Center , Nashville, TN 37240-7915.
Weijing KongDepartment of Pediatrics, Peking University First Hospital , Beijing, China 100034.
Ningning HuDepartment of Neurology, Vanderbilt University Medical Center , Nashville, TN 37240-7915.ORCID 0000-0002-4854-6219
Yujia ZhangDepartment of Pediatrics, Peking University First Hospital , Beijing, China 100034.
Wangzhen ShenDepartment of Neurology, Vanderbilt University Medical Center , Nashville, TN 37240-7915.ORCID 0000-0002-1784-511X
Laurel JacksonDepartment of Neurology, Vanderbilt University Medical Center , Nashville, TN 37240-7915.
Xiaoyan LiuDepartment of Pediatrics, Peking University First Hospital , Beijing, China 100034.
Yuwu JiangDepartment of Pediatrics, Peking University First Hospital , Beijing, China 100034.
Robert L MacdonaldDepartment of Neurology, Vanderbilt University Medical Center , Nashville, TN 37240-7915.ORCID 0000-0002-9539-5556
Vanderbilt University Medical Center · USPeking University · CN

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
RECOMBINANT/NATIVE GABAA RECEPTORSR01NS033300 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MACDONALD, ROBERT LOUDEN · 1995 to 2016
$5.0M
NICHD NIH HHS U54 HD083211NINDS NIH HHS R01 NS033300
6 · The paper itself

Abstract

We identified a

Indexed as

Mutation, MissenseAnimalsCell MembraneCerebral CortexEpilepsies, MyoclonicHEK293 CellsHumansInhibitory Postsynaptic PotentialsMice, Inbred C57BLMiniature Postsynaptic PotentialsModels, MolecularNeuronsReceptors, GABA-ARecombinant ProteinsZincGABRG2 protein, humanReceptors, GABA-ARecombinant ProteinsZincconductance statesDravet syndromeGABRG2gatingpore mutationstructural modeling

Identifiers

PMID28197552
PMCPMC5301078
OpenAlexW2585027936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.