ArticleeNeuro
Sexually Dimorphic Risk Mitigation Strategies in Rats.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed.
- Sex differences in exploration-exploitation strategies during home-cage decision making.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in task engagement and lapse rate during reward learning.Oxford open neuroscience · 2026Article
- Sex-specific exploration accounts for differences in valence learning in male and female mice.eLife · 2025Article
- Data-Driven Analysis Identifies Novel Modulation of Social Behavior in Female Mice Witnessing Chronic Social Defeat Stress.Biological psychiatry · 2025Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.Neurobiology of stress · 2024Article
- Looming stimuli reliably drive innate defensive responses in male rats, but not learned defensive responses.Scientific reports · 2024Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics.Neurobiology of stress · 2024Article
- Enhancing Associative Learning in Rats With a Computationally Designed Training Protocol.Biological psychiatry global open science · 2024Article
- Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.The European journal of neuroscience · 2023Article
- Sex differences in learning and performing the Go/NoGo tasks.Biology of sex differences · 2023Article
- Reward maximization assessed using a sequential patch depletion task in a large sample of heterogeneous stock rats.Scientific reports · 2023Article
- Bed Nucleus of the Stria Terminalis GABA neurons are necessary for changes in foraging behavior following an innate threat.bioRxiv : the preprint server for biology · 2023Article
- Temporal Dynamics Underlying Prelimbic Prefrontal Cortical Regulation of Action Selection and Outcome Evaluation during Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reward Maximization Assessed Using a Sequential Patch Depletion Task in a Large Sample of Heterogeneous Stock Rats.Research square · 2023Article
- A neural substrate of sex-dependent modulation of motivation.Nature neuroscience · 2023Article
- Sex differences in patch-leaving foraging decisions in rats.Oxford open neuroscience · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The scientific understanding of fear and anxiety-in both normal and pathological forms-is presently limited by a predominance of studies that use male animals and Pavlovian fear conditioning-centered paradigms that restrict and assess specific behaviors (e.g., freezing) over brief sampling periods and overlook the broader contributions of the spatiotemporal context to an animal's behavioral responses to threats. Here, we use a risky "closed economy" system, in which the need to acquire food and water and the need to avoid threats are simultaneously integrated into the lives of rats, to examine sex differences in mitigating threat risk while foraging. Rats lived for an extended period (∼2 months) in enlarged chambers that consisted of a safe, bedded nest and a risky foraging area where footshocks could be delivered unpredictably. We observed that male and female rats used different strategies for responding to the threat of footshock. Whereas male rats increased the size of meals consumed to reduce the overall time spent foraging, female rats sacrificed their metabolic needs in order to avoid shocks. Ovarian hormone fluctuations were shown to exert slight but reliable rhythmic effects on risky decision-making in gonadally intact female rats. However, this did not produce significant differences in approach-avoidance trade-offs between ovariectomized and intact female groups, suggesting that male-female sex differences are not due to the activational effects of gonadal hormones but, rather, are likely to be organized during early development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.