Evidence map›Paper›PMID 28197369›Full record

ArticleOncoimmunology

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome.

Lotte Pyfferoen, Elisabeth Brabants, Celine Everaert, Nancy De Cabooter, Kelly Heyns, Kim Deswarte, Manon Vanheerswynghels, Sofie De Prijck, Glenn Waegemans, Melissa Dullaers and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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  11. [Role and Significance of Bioactive Substances in Sputum
 in the Diagnosis of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Lotte PyfferoenTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Ghent, Belgium.
Elisabeth BrabantsTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium.
Celine EveraertCenter for Medical Genetics, Ghent University , Ghent, Belgium.
Nancy De CabooterTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium.
Kelly HeynsTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium.
Kim DeswarteVIB Inflammation Research Center , Ghent, Belgium.
Manon VanheerswynghelsVIB Inflammation Research Center , Ghent, Belgium.
Sofie De PrijckVIB Inflammation Research Center , Ghent, Belgium.
Glenn WaegemansLaboratory of Experimental Cancer Research, Ghent University , Ghent, Belgium.
Melissa DullaersTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Ghent, Belgium.
Hamida HammadVIB Inflammation Research Center , Ghent, Belgium.
Olivier De WeverLaboratory of Experimental Cancer Research, Ghent University , Ghent, Belgium.
Pieter MestdaghCenter for Medical Genetics, Ghent University , Ghent, Belgium.
Jo VandesompeleCenter for Medical Genetics, Ghent University , Ghent, Belgium.
Bart N LambrechtVIB Inflammation Research Center, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Karim Y VermaelenTumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium.
Ghent University Hospital · BEVIB-UGent Center for Inflammation Research · BECancer Research Institute Ghent · BEErasmus MC · NLGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting immunomodulatory pathways has ushered a new era in lung cancer therapy. Further progress requires deeper insights into the biology of immune cells in the lung cancer micro-environment. Dendritic cells (DCs) represent a heterogeneous and highly plastic immune cell system with a central role in controlling immune responses. The intratumoral infiltration and activation status of DCs are emerging as clinically relevant parameters in lung cancer. In this study, we used an orthotopic preclinical model of lung cancer to dissect how the lung tumor micro-environment affects tissue-resident DCs and extract novel biologically and clinically relevant information. Lung tumor-infiltrating leukocytes expressing generic DC markers were found to predominantly consist of CD11b

Indexed as

Dendritic cellhypoxialung cancermiR-31PD-L1

Identifiers

PMID28197369
PMCPMC5283643
OpenAlexW2549131319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.