Evidence map›Paper›PMID 28197362›Full record

ArticleOncoimmunology

Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer.

Laetitia Fend, Sylvie Rusakiewicz, Julien Adam, Bérangère Bastien, Anne Caignard, Meriem Messaoudene, Christina Iribarren, Isabelle Cremer, Aurélien Marabelle, Christophe Borg and 6 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Laetitia FendTransgene S.A, Parc d'innovation, Illkirch-Graffenstaden Cedex, France; Gustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France.
Sylvie RusakiewiczGustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT), GRCC, Villejuif, France.
Julien AdamGustave Roussy Cancer Campus (GRCC), Villejuif, France; Department of Pathology, GRCC, Villejuif, France; INSERM, GRCC, Villejuif, France.
Bérangère BastienTransgene S.A, Parc d'innovation , Illkirch-Graffenstaden Cedex, France.
Anne CaignardINSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Institut Universitaire d'Hématologie, Hôpital Saint Louis, Paris, France.
Meriem MessaoudeneGustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France.
Christina IribarrenEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; INSERM, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.
Isabelle CremerUniversité Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; INSERM, Center de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie, Paris, France.
Aurélien MarabelleGustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Drug Development Department (DITEP), GRCC, Villejuif, France.
Christophe BorgINSERM, Unité Mixte de Recherche, University of Franche-Comté, Besançon, France; Etablissement Français du Sang de Bourgogne Franche-Comté, Besançon, France; Université de Franche-Comté, Besançon, France.
Michaela SemeraroGustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; Department of Pediatric Oncology, GRCC, Villejuif, France.
Luc BarraudTransgene S.A, Parc d'innovation , Illkirch-Graffenstaden Cedex, France.
Jean-Marc LimacherTransgene S.A, Parc d'innovation , Illkirch-Graffenstaden Cedex, France.
Alexander EggermontGustave Roussy Cancer Campus (GRCC) , Villejuif, France.
Guido KroemerEquipe 11 labellisée par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France; INSERM, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Metabolomics and Cell Biology Platforms, GRCC, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Laurence ZitvogelGustave Roussy Cancer Campus (GRCC), Villejuif, France; INSERM, GRCC, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT), GRCC, Villejuif, France; University of Paris Sud XI, Kremlin Bicêtre, France; Department of Immuno-Oncology, GRCC, Villejuif, France.
Inserm · FRTransgene (France) · FRDélégation Paris 5 · FRInstitut Gustave Roussy · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The putative contribution of natural killer (NK) cells to immunosurveillance in non-small cell lung cancer (NSCLC) has been an ongoing conundrum. Here, we used a readily standardizable quantitative real time polymerase chain reaction (qRT-PCR) to measure the expression of NK cell receptors in total peripheral blood mononuclear cells (PBMC) from healthy volunteers (HV), patients with gastrointestinal stromal tumors (GIST), neuroblastoma (NB), melanoma or NSCLC. We quantified

Indexed as

BiomarkerNK cellsNKp30NKp46NSCLCPD-L1

Identifiers

PMID28197362
PMCPMC5283624
OpenAlexW2373400824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.