Evidence map›Paper›PMID 28197317›Full record

ArticleACS medicinal chemistry letters2017

Comparison of Fluorinated and Nonfluorinated Lipids in Self-Adjuvanting Delivery Systems for Peptide-Based Vaccines.

Waleed M Hussein, Saori Mukaida, Fazren Azmi, Stacey Bartlett, Celine Olivier, Michael R Batzloff, Michael F Good, Mariusz Skwarczynski, Istvan Toth

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Waleed M HusseinSchool of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Saori MukaidaSchool of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Fazren AzmiSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Faculty of Pharmacy, National University of Malaysia, Kuala Lumpur, Malaysia.
Stacey BartlettSchool of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Celine OlivierSchool of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Michael R BatzloffInstitute for Glycomics, Griffith University , Gold Coast, QLD 4215, Australia.
Michael F GoodInstitute for Glycomics, Griffith University , Gold Coast, QLD 4215, Australia.
Mariusz SkwarczynskiSchool of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, QLD 4072, Australia.
Istvan TothSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
The University of Queensland · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.

Indexed as

cellular immunityFluorinated lipidhumoral immunitynanoparticlepeptide-based vaccineself-adjuvant

Identifiers

PMID28197317
PMCPMC5304309
OpenAlexW2583064354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.