Evidence map›Paper›PMID 28197306›Full record

ArticleACS medicinal chemistry letters2017

Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against

Aaron D Mood, Ilandari Dewage Udara Anulal Premachandra, Stanley Hiew, Fuqiang Wang, Kevin A Scott, Nathan J Oldenhuis, Haoping Liu, David L Van Vranken

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. The Role of miRNA in the Pathophysiology of Neuroendocrine Tumors.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aaron D MoodDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
Ilandari Dewage Udara Anulal PremachandraDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
Stanley HiewDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
Fuqiang WangDepartment of Biological Chemistry, University of California , Irvine, California 92697-1700, United States.
Kevin A ScottDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
Nathan J OldenhuisDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
Haoping LiuDepartment of Biological Chemistry, University of California , Irvine, California 92697-1700, United States.
David L Van VrankenDepartment of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.

Funding

REGULATION OF FILAMENTOUS GROWTH IN YEASTR01GM055155 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, HAOPING · 1997 to 2013
$4.1M
Signal sensing, hyphal development and pathognesis of Candida albicansR01GM117111 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, HAOPING · 2017 to 2024
$3.8M
Dissecting triazole resistance and transcriptional regulation of ergosterol homeoR01AI099190 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, HAOPING · 2012 to 2016
$3.1M
NIAID NIH HHS R01 AI099190NIGMS NIH HHS R01 GM055155NIGMS NIH HHS R01 GM117111
6 · The paper itself

Abstract

Four phthalazinones (CIDs 22334057, 22333974, 22334032, 22334012) and one isoquinolone (CID 5224943) were previously shown to be potent enhancers of antifungal activity of fluconazole against

Indexed as

antifungal agentsCandida albicansfluconazoleisoquinolonephthalazinonesynergy

Identifiers

PMID28197306
PMCPMC5304299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.