ArticleCardiology research2016
Significant Increase in C-Reactive Protein and Serum Amyloid A in the Early Hours of Paroxysmal Atrial Fibrillation.
Article in Cardiology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation.The Journal of innovations in cardiac rhythm management · 2022Article
- Plasma proteomic analysis of association between atrial fibrillation, coronary microvascular disease and heart failure.American journal of cardiovascular disease · 2022Article
- The Predictive Role of Inflammatory Biomarkers in Atrial Fibrillation as Seen through Neutrophil-Lymphocyte Ratio Mirror.Journal of biomarkers · 2016Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA number of data have been accumulated on inflammation in persistent and permanent atrial fibrillation (AF). Our aim was to study the process in paroxysmal AF (PAF) by measuring plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA) and fibrinogen in dynamics.
methodsThe markers were investigated in 51 patients (26 males and 25 females; 59.84 ± 1.60 years) at hospital admission (baseline), 24 hours and 28 days after sinus rhythm restoration. Fifty-two controls (26 males and 26 females; 59.50 ± 1.46 years) were selected.
resultsAt baseline, hs-CRP and SAA concentrations were higher in patients (8.12 ± 0.82 vs. 5.57 ± 0.21 mg/L, P = 0.003; 16.04 ± 0.93 vs. 5.12 ± 0.23 ng/mL, P < 0.001, respectively) and these changes persisted 24 hours after sinus rhythm restoration (8.16 ± 0.71 vs. 5.57 ± 0.21 mg/L, P < 0.001; 12.99 ± 0.75 vs. 5.12 ± 0.23 ng/mL, P < 0.001, respectively). On the 28th day, no significant difference was measured (5.42 ± 0.29 vs. 5.57 ± 0.21 mg/L, P = 0.68; 5.89 ± 0.38 vs. 5.12 ± 0.23 ng/mL, P = 0.08, respectively). At any measurement, fibrinogen levels did not differ between patients and controls (3.30 ± 0.17 vs. 3.22 ± 0.11 g/L, P = 0.70; 3.32 ± 0.11 vs. 3.22 ± 0.11 g/L, P = 0.52; 3.24 ± 0.13 vs. 3.22 ± 0.11 g/L, P = 0.90, respectively).
conclusionPAF is associated with dynamics in hs-CRP and SAA plasma levels. The results suggest that inflammation is closely related to the arrhythmia initiation.
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