ArticleNeural regeneration research2016
Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.
Article in Neural regeneration research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Electron-rearranged CuMg@ZIF nanoplatform for pH-Responsive sequential therapy: From infection eradication to neuroangiogenesis in diabetic wounds.Bioactive materials · 2027Article
- From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.Bioactive materials · 2026Review
- Multifunctional Roles of Magnesium Ions in Modulating Bone Regeneration-Related Cells.Bioengineering (Basel, Switzerland) · 2026Article
- Magnesium and nerve injury: Mechanisms and applications.Neural regeneration research · 2026Article
- Engineering a functional tendon-bone interface: mechanisms and prospects of magnesium alloys in promoting neurotized regeneration via modulating stem cell-nerve interplay.Frontiers in medicine · 2026Review
- Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fabrication of GDNF-Gel/HA-Mg nerve conduit and its role in repairing peripheral nerve defects.Materials today. Bio · 2025Article
- The Impact of Chronic Magnesium Deficiency on Excitable Tissues-Translational Aspects.Biological trace element research · 2025Review
- Research Progress of Magnesium Alloys and Its Alloys in Medical Applications.International journal of general medicine · 2025Review
- Metal-Based Regenerative Strategies for Peripheral Nerve Injuries: From Biodegradable Ion Source to Stable Conductive Implants.Biomaterials research · 2025Review
- Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model.Journal of functional biomaterials · 2024Article
- The GDNF-gel/HA-Mg conduit promotes the repair of peripheral nerve defects by regulating PPAR-γ/RhoA/ROCK signaling pathway.iScience · 2024Article
- A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats.Neural regeneration research · 2023Article
- Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review).Journal of orthopaedic translation · 2022Review
- Magnesium-Encapsulated Injectable Hydrogel and 3D-Engineered Polycaprolactone Conduit Facilitate Peripheral Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A review of the diet, nutrients, and supplementation potential for the outcome augmentation in surgical treatment of peripheral nerve injuries.Frontiers in surgery · 2022Review
- The Role of Dietary Nutrients in Peripheral Nerve Regeneration.International journal of molecular sciences · 2021Review
- Magnesium Promotes the Regeneration of the Peripheral Nerve.Frontiers in cell and developmental biology · 2021Review
- Effect of chitosan combined with hyaluronate on promoting the recovery of postoperative facial nerve regeneration and function in rabbits.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.