ArticleFrontiers in microbiology2017
Drivers of Bacterial Maintenance and Minimal Energy Requirements.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Amplification of computational power by the multiplication of bacteria exploring microfluidic networks encoding mathematical problems.Microsystems & nanoengineering · 2026Article
- The Maximum Growth Temperature for Eukaryotes Is Thermodynamically Driven but Ecologically Contingent.Life (Basel, Switzerland) · 2026Article
- When energy is scarce, evolution selects dormancy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A novel method to simultaneously estimate bacterial respiration and growth from oxygen dynamics.ISME communications · 2026Article
- Metabolically flexible microorganisms rapidly establish glacial foreland ecosystems.Nature communications · 2025Article
- Origins of life: the possible and the actual.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- How hard is it to encapsulate life? The general constraints on encapsulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Bacteriophage T4 propagation in E.coli exposed to severe substrate limitation.Virology journal · 2025Article
- Constraints in temperature adaptation reinforce differences in thermal niche between mesophilic and psychrotolerantProceedings. Biological sciences · 2025Article
- Risk-reward trade-off during carbon starvation generates dichotomy in motility endurance among marine bacteria.Nature microbiology · 2025Article
- Energetic investigations of Acidianus ambivalens metabolism during anaerobic sulfur reduction and comparisons to aerobic sulfur oxidation.Extremophiles : life under extreme conditions · 2025Article
- The metabolic burden associated with plasmid acquisition: An assessment of the unrecognized benefits to host cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Long-term biogas slurry fertilization alters rhizosphere soil metabolite profiles and microbial communities in poplar plantations.Frontiers in microbiology · 2025Article
- Soil fungi remain active and invest in storage compounds during drought independent of future climate conditions.Nature communications · 2024Article
- Prokaryotic morphological features and maintenance activities governed by seasonal productivity conditions.FEMS microbiology ecology · 2024Article
- Bioenergetic characterization of hyperthermophilic archaean Methanocaldococcus sp. FS406-22.Extremophiles : life under extreme conditions · 2024Article
- Article
- Sub-inhibitory antibiotic treatment selects for enhanced metabolic efficiency.Microbiology spectrum · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbes maintain themselves through a variety of processes. Several of these processes can be reduced or shut down entirely when resource availability declines. In pure culture conditions with ample substrate supply, a relationship between the maximum growth rate and the energy invested in maintenance has been reported widely. However, at the other end of the resources spectrum, bacteria are so extremely limited by energy that no growth occurs and metabolism is constrained to the most essential functions only. These minimum energy requirements have been called the basal power requirement. While seemingly different from each other, both aspects are likely components of a continuum of regulated maintenance processes. Here, we analyze cross-species tradeoffs in cellular physiology over the range of bacterial size and energy expenditure and determine the contributions to maintenance metabolism at each point along the size-energy spectrum. Furthermore, by exploring the simplest bacteria within this framework- which are most affected by maintenance constraints- we uncover which processes become most limiting. For the smallest species, maintenance metabolism converges on total metabolism, where we predict that maintenance is dominated by the repair of proteins. For larger species the relative costs of protein repair decrease and maintenance metabolism is predicted to be dominated by the repair of RNA components. These results provide new insights into which processes are likely to be regulated in environments that are extremely limited by energy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.