Evidence map›Paper›PMID 28197125›Full record

ArticleFrontiers in neurology2017

RNA Interference of Human α-Synuclein in Mouse.

Young-Cho Kim, Adam Miller, Livia C R F Lins, Sang-Woo Han, Megan S Keiser, Ryan L Boudreau, Beverly L Davidson, Nandakumar S Narayanan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. "Janus-Faced" α-Synuclein: Role in Parkinson's Disease.Frontiers in cell and developmental biology · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.Molecular therapy : the journal of the American Society of Gene Therapy · 2019
    Article
  15. Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound.Movement disorders : official journal of the Movement Disorder Society · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Young-Cho KimDepartment of Neurology, University of Iowa Hospitals and Clinics , Iowa City, IA , USA.
Adam MillerDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Aging Mind and Brain Initiative, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Livia C R F LinsDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil.
Sang-Woo HanDepartment of Neurology, University of Iowa Hospitals and Clinics , Iowa City, IA , USA.
Megan S KeiserChildren's Hospital of Philadelphia , Philadelphia, PA , USA.
Ryan L BoudreauDepartment of Internal Medicine, University of Iowa Hospitals and Clinics , Iowa City, IA , USA.
Beverly L DavidsonChildren's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Nandakumar S NarayananDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Aging Mind and Brain Initiative, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
University of Iowa Hospitals and Clinics · USChildren's Hospital of Philadelphia · USUniversidade Federal de Sergipe · BR

Funding

Prefrontal D1 signaling and cognitive symptoms of Parkinson's diseaseR01NS089470 · NINDS · UNIVERSITY OF IOWA · PI NARAYANAN, NANDAKUMAR · 2014 to 2018
$1.6M
NINDS NIH HHS R01 NS089470
6 · The paper itself

Abstract

α-Synuclein is postulated to play a key role in the pathogenesis of Parkinson's disease (PD). Aggregates of α-synuclein contribute to neurodegeneration and cell death in humans and in mouse models of PD. Here, we use virally mediated RNA interference to knockdown human α-synuclein in mice. We used an siRNA design algorithm to identify eight siRNA sequences with minimal off-targeting potential. One RNA-interference sequence (miSyn4) showed maximal protein knockdown potential

Indexed as

neurodegenerationParkinson’s diseaseRNA interferencesiRNAα-synuclein

Identifiers

PMID28197125
PMCPMC5281542
OpenAlexW2582529012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.