Evidence map›Paper›PMID 28197106›Full record

ArticleFrontiers in physiology2017

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C.

Aida Oliván-Viguera, Javier Lozano-Gerona, Laura López de Frutos, Jorge J Cebolla, Pilar Irún, Edgar Abarca-Lachen, Ana J García-Malinis, Ángel Luis García-Otín, Yolanda Gilaberte, Pilar Giraldo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The Antitumor Effects of α-Linolenic Acid.Journal of personalized medicine · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Aida Oliván-VigueraBiomedical Signal Interpretation and Computational Simulation Group, Aragón Institute for Engineering Research (I3A), University of ZaragozaZaragoza, Spain; Instituto de Investigación Sanitaria AragónZaragoza, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and NanomedicineZaragoza, Spain.
Javier Lozano-GeronaInstituto de Investigación Sanitaria AragónZaragoza, Spain; Aragón Institute of Health SciencesZaragoza, Spain; Departamento de Bioquímica, Biología Molecular y Celular, Facultad de Ciencias, Universidad de ZaragozaZaragoza, Spain.
Laura López de FrutosInstituto de Investigación Sanitaria AragónZaragoza, Spain; Spanish Foundation for the Study and Treatment of Gaucher Disease and Other Lysosomal DisordersZaragoza, Spain.
Jorge J CebollaInstituto de Investigación Sanitaria AragónZaragoza, Spain; Departamento de Bioquímica, Biología Molecular y Celular, Facultad de Ciencias, Universidad de ZaragozaZaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades RarasZaragoza, Spain.
Pilar IrúnInstituto de Investigación Sanitaria AragónZaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades RarasZaragoza, Spain.
Edgar Abarca-LachenFaculty of Health Sciences, Universidad San Jorge Villanueva de Gállego, Spain.
Ana J García-MalinisService of Dermatology, Hospital San Jorge Huesca, Spain.
Ángel Luis García-OtínInstituto de Investigación Sanitaria AragónZaragoza, Spain; Aragón Institute of Health SciencesZaragoza, Spain.
Yolanda GilaberteService of Dermatology, Hospital San Jorge Huesca, Spain.
Pilar GiraldoInstituto de Investigación Sanitaria AragónZaragoza, Spain; Aragón Institute of Health SciencesZaragoza, Spain; Spanish Foundation for the Study and Treatment of Gaucher Disease and Other Lysosomal DisordersZaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades RarasZaragoza, Spain.
Ralf KöhlerInstituto de Investigación Sanitaria AragónZaragoza, Spain; Aragón Institute of Health SciencesZaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades RarasZaragoza, Spain; Aragón Agency for Research and DevelopmentZaragoza, Spain.
Centro de Investigación Biomédica en Red · ESHospital General San Jorge · ESInstituto de Investigación Sanitaria Aragón · ESUniversidad de Zaragoza · ESCentre for Biomedical Network Research on Rare Diseases · ESUniversidad San Jorge · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K

Indexed as

fabry diseasefibroblastsion channel pharmacologyKCa3.1/SK4 channellinolenic acids

Identifiers

PMID28197106
PMCPMC5281581
OpenAlexW2582990558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.