ArticleFrontiers in synaptic neuroscience2017
Ultrastructural and Functional Properties of a Giant Synapse Driving the Piriform Cortex to Mediodorsal Thalamus Projection.
Article in Frontiers in synaptic neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice.Nature communications · 2026Article
- Invaginating Structures in Synapses - Perspective.Frontiers in synaptic neuroscience · 2021Article
- Cortical Hub for Flavor Sensation in Rodents.Frontiers in systems neuroscience · 2021Review
- Synaptic organization of cortico-cortical communication in primates.The European journal of neuroscience · 2020Article
- A specific olfactory cortico-thalamic pathway contributing to sampling performance during odor reversal learning.Brain structure & function · 2019Article
- Experience-Dependent c-Fos Expression in the Mediodorsal Thalamus Varies With Chemosensory Modality.Chemical senses · 2019Article
- Differentiating Cerebellar Impact on Thalamic Nuclei.Cell reports · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Neocortico-thalamo-cortical loops represent a common, yet poorly understood, circuit employing giant synapses also referred to as "class I", giant, or driver synapses. Here, we characterize a giant synapse formed by projection neurons of the paleocortical piriform cortex (PIR) onto neurons of the mediodorsal thalamus (MD). Three-dimensional (3D) ultrastructure of labeled PIR-MD terminals, obtained by using serial-section scanning electron microscopy (EM) combined with photooxidation-based detection of labeled terminals, revealed a large terminal engulfing multiple postsynaptic dendritic excrescences. The terminal contained multiple synaptic contacts, a high density of synaptic vesicles and several central mitochondria. Using targeted stimulations of single identified PIR-MD terminals in combination with patch-clamp recordings from the connected MD neuron, we found large postsynaptic currents with fast kinetics and strong short-term depression, yet fast recovery upon repetitive stimulation. We conclude that the phylogenetically old paleocortex already developed giant synaptic connections exhibiting similar functional properties as connections formed by giant neocortico-thalamic projections.
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