ArticleProceedings of the National Academy of Sciences of the United States of America2017
Spontaneous activity in the piriform cortex extends the dynamic range of cortical odor coding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 49 citations in OpenAlex.
- EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia.Science advances · 2025Article
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- Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex.Nature communications · 2024Article
- Semantic context-dependent neural representations of odors in the human piriform cortex revealed by 7T MRI.Human brain mapping · 2024Article
- Experience-dependent evolution of odor mixture representations in piriform cortex.PLoS biology · 2023Article
- Long-range functional loops in the mouse olfactory system and their roles in computing odor identity.Neuron · 2022Article
- Article
- TNF-α Orchestrates Experience-Dependent Plasticity of Excitatory and Inhibitory Synapses in the Anterior Piriform Cortex.Frontiers in neuroscience · 2022Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
- Dopamine Increases the Intrinsic Excitability of Parvalbumin-Expressing Fast-Spiking Cells in the Piriform Cortex.Frontiers in cellular neuroscience · 2022Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Target-specific control of piriform cortical output via distinct inhibitory circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.Journal of neurophysiology · 2021Article
- Combined Neural Tuning in Human Ventral Temporal Cortex Resolves the Perceptual Ambiguity of Morphed 2D Images.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Perspective on the Multiple Pathways to Changing Brain States.Frontiers in systems neuroscience · 2020Review
- Coding of odors in the anterior olfactory nucleus.Physiological reports · 2019Article
- Psychotropic Drugs for the Management of Chronic Pain and Itch.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Superficial Layers Suppress the Deep Layers to Fine-tune Cortical Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons in the neocortex exhibit spontaneous spiking activity in the absence of external stimuli, but the origin and functions of this activity remain uncertain. Here, we show that spontaneous spiking is also prominent in a sensory paleocortex, the primary olfactory (piriform) cortex of mice. In the absence of applied odors, piriform neurons exhibit spontaneous firing at mean rates that vary systematically among neuronal classes. This activity requires the participation of NMDA receptors and is entirely driven by bottom-up spontaneous input from the olfactory bulb. Odor stimulation produces two types of spatially dispersed, odor-distinctive patterns of responses in piriform cortex layer 2 principal cells: Approximately 15% of cells are excited by odor, and another approximately 15% have their spontaneous activity suppressed. Our results show that, by allowing odor-evoked suppression as well as excitation, the responsiveness of piriform neurons is at least twofold less sparse than currently believed. Hence, by enabling bidirectional changes in spiking around an elevated baseline, spontaneous activity in the piriform cortex extends the dynamic range of odor representation and enriches the coding space for the representation of complex olfactory stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.