ArticleProceedings of the National Academy of Sciences of the United States of America2017
Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- The most fundamental and popular literature on functional near-infrared spectroscopy: a bibliometric analysis of the top 100 most cited articles.Frontiers in neurology · 2024Pooled it
- Cortical Contributions to Attentional Orienting and Response Cancellation in Action Stopping.Psychophysiology · 2026Article
- Understanding variability in full-term newborns' fNIRS data: the impact of birth weight and gestational age on infants' speech perception abilities.Neurophotonics · 2026Article
- Brain network characteristics and behavioral correlations in global developmental delay based on functional near-infrared spectroscopy.iScience · 2026Article
- Differences in brain function in cognitive impairment after stroke in different hemispheres of the brain: a functional near-infrared spectroscopy study.BMC neurology · 2026Article
- Evidence of Top-Down Sensory Prediction in Neonates Within 2 Days of Birth.Developmental science · 2026Article
- Frontal Cortex Entropy Derived From Resting-State fNIRS for Brain Age Prediction in Major Depressive Disorder.Depression and anxiety · 2026Article
- Bilateral Prefrontal Cortex Activation During Sensorimotor Tasks in People with Subacute Stroke - An Exploratory Functional Near-Infrared Spectroscopy Study.NeuroRehabilitation · 2025Article
- Exploring Effects of Mental Stress with Data Augmentation and Classification Using fNIRS.Sensors (Basel, Switzerland) · 2025Article
- Monitoring neonatal brain function: recent advances in functional near-infrared spectroscopy (fNIRS).Frontiers in pediatrics · 2025Review
- Haemodynamic Responses to Spontaneous Neural Activity on the Electroencephalogram in Preterm Infants.Advances in experimental medicine and biology · 2024Article
- Age-dependent neurovascular coupling characteristics in children and adults during general anesthesia.Biomedical optics express · 2023Article
- Using functional near-infrared spectroscopy to study the early developing brain: future directions and new challenges.Neurophotonics · 2023Article
- mHealth hyperspectral learning for instantaneous spatiospectral imaging of hemodynamics.PNAS nexus · 2023Article
- Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children.Children (Basel, Switzerland) · 2023Article
- The use of functional near-infrared spectroscopy in tracking neurodevelopmental trajectories in infants and children with or without developmental disorders: a systematic review.Frontiers in psychiatry · 2023Review
- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS.Advances in experimental medicine and biology · 2023Article
- Differential age-dependent development of inter-area brain connectivity in term and preterm neonates.Pediatric research · 2022Article
- Low fraction of fetal haemoglobin is associated with retinopathy of prematurity in the very preterm infant.The British journal of ophthalmology · 2022Observational
- Open access dataset of task-free hemodynamic activity in 4-month-old infants during sleep using fNIRS.Scientific data · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A crucial issue in neonatal medicine is the impact of preterm birth on the developmental trajectory of the brain. Although a growing number of studies have shown alterations in the structure and function of the brain in preterm-born infants, we propose a method to detect subtle differences in neurovascular and metabolic functions in neonates and infants. Functional near-infrared spectroscopy (fNIRS) was used to obtain time-averaged phase differences between spontaneous low-frequency (less than 0.1 Hz) oscillatory changes in oxygenated hemoglobin (oxy-Hb) and those in deoxygenated hemoglobin (deoxy-Hb). This phase difference was referred to as hemoglobin phase of oxygenation and deoxygenation (hPod) in the cerebral tissue of sleeping neonates and infants. We examined hPod in term, late preterm, and early preterm infants with no evidence of clinical issues and found that all groups of infants showed developmental changes in the values of hPod from an in-phase to an antiphase pattern. Comparison of hPod among the groups revealed that developmental changes in hPod in early preterm infants precede those in late preterm and term infants at term equivalent age but then, progress at a slower pace. This study suggests that hPod measured using fNIRS is sensitive to the developmental stage of the integration of circular, neurovascular, and metabolic functions in the brains of neonates and infants.
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