Evidence map›Paper›PMID 28196879›Full record

ArticleThe Journal of general physiology2017

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels.

Guohui Zhang, Yanyan Geng, Yakang Jin, Jingyi Shi, Kelli McFarland, Karl L Magleby, Lawrence Salkoff, Jianmin Cui

Abstract read
In one paragraph

Article in The Journal of general physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Redox-dependent CdBiophysical journal · 2024
    Article
  6. Fifty years of gating currents and channel gating.The Journal of general physiology · 2023
    Review
  7. Article
  8. Cholesterol and PIPAdvances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy.Movement disorders : official journal of the Movement Disorder Society · 2020
    Article
  13. A PIPCommunications biology · 2020
    Article
  14. Article
  15. Coupling of CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Guohui ZhangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO 63130.
Yanyan GengDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136.ORCID http://orcid.org/0000-0001-5605-6116
Yakang JinDepartment of Pharmacology, Soochow University College of Pharmaceutical Sciences, Suzhou 215123, China.ORCID http://orcid.org/0000-0002-7728-4174
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO 63130.
Kelli McFarlandDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO 63130.
Karl L MaglebyDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136.
Lawrence SalkoffDepartment of Anatomy and Neurobiology (Department of Neuroscience), Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO 63130 jcui@wustl.edu.ORCID http://orcid.org/0000-0002-9198-6332

Funding

Ca2+ Dependent K+ Channels: Allosteric GatingR01HL070393 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2002 to 2015
$4.9M
Testing a Novel Push-Pull Mechanism for Ca2+-Dependent Coupling in BK ChannelsR01GM114694 · NIGMS · WASHINGTON UNIVERSITY · PI MAGLEBY, KARL L, SALKOFF, LAWRENCE B · 2016 to 2019
$1.9M
KCNQ CHANNELS: GATING AND SUBUNITS MODULATIONR01NS092570 · NINDS · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2015 to 2020
$1.7M
NHLBI NIH HHS R01 HL070393NIGMS NIH HHS R01 GM114694NINDS NIH HHS R01 NS092570
6 · The paper itself

Abstract

Large conductance Ca

Indexed as

Models, TheoreticalAnimalsCalciumIon Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsMembrane PotentialsOocytesPatch-Clamp TechniquesXenopus laevisCalciumLarge-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID28196879
PMCPMC5339509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.