Evidence map›Paper›PMID 28196869›Full record

ArticleThe Journal of biological chemistry2017

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from

Anja Pomowski, Isabel Usón, Zuzanna Nowakowska, Florian Veillard, Maryta N Sztukowska, Tibisay Guevara, Theodoros Goulas, Danuta Mizgalska, Magdalena Nowak, Barbara Potempa and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Biochemical and functional characterization ofFrontiers in microbiology · 2026
    Article
  2. Discovery of Gingipains andFoods (Basel, Switzerland) · 2025
    Review
  3. cAMP-independent Crp homolog adds to the multi-layer regulatory network inFrontiers in cellular and infection microbiology · 2025
    Article
  4. First crystal structure of the DUF2436 domain of virulence proteins from Porphyromonas gingivalis.Acta crystallographica. Section F, Structural biology communications · 2024
    Article
  5. Comparative analysis ofMicrobiology spectrum · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pathogenesis of Important Virulence Factors ofFrontiers in cellular and infection microbiology · 2019
    Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Anja PomowskiFrom the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.
Isabel Usónthe Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
Zuzanna Nowakowskathe Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
Florian Veillardthe Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
Maryta N Sztukowskathe Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
Tibisay Guevarathe Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
Theodoros Goulasthe Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain.
Danuta Mizgalskathe Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
Magdalena Nowakthe Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and.
Barbara Potempathe Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, Kentucky 40202.
James A HuntingtonFrom the Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.
Jan Potempathe Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland, and jan.potempa@louisville.edu.
F Xavier Gomis-Rüththe Proteolysis Lab and Crystallographic Methods Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas, 08028 Barcelona, Catalonia, Spain, fxgr@ibmb.csic.es.
University of Louisville · USInstitut de Biologia Molecular de Barcelona · ESJagiellonian University · PLUniversity of Cambridge · GBConsejo Superior de Investigaciones Científicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skewing of the human oral microbiome causes dysbiosis and preponderance of bacteria such as

Indexed as

Adhesins, BacterialBacteroidaceae InfectionsCysteine EndopeptidasesEnzyme PrecursorsGingipain Cysteine EndopeptidasesGingivitisHumansMicrobiotaMouthPorphyromonas gingivalisProtein DomainsProtein MultimerizationStructure-Activity RelationshipVirulence FactorsAdhesins, BacterialCysteine EndopeptidasesEnzyme PrecursorsGingipain Cysteine EndopeptidasesVirulence Factorscysteine proteasehost-microbiome interactionoral microbiotaproteinaseprotein crystallizationprotein degradationprotein domainprotein structureX-ray crystal structurezymogenic latency

Identifiers

PMID28196869
PMCPMC5392567
OpenAlexW2588638177

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.