Evidence map›Paper›PMID 28196854›Full record

ArticlePhysiological reports2017

Hypothalamic transcriptomic alterations in male and female California mice (

Sarah A Johnson, William G Spollen, Lindsey K Manshack, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah A JohnsonBond Life Sciences Center, University of Missouri, Columbia, Missouri.
William G SpollenBond Life Sciences Center, University of Missouri, Columbia, Missouri.
Lindsey K ManshackBond Life Sciences Center, University of Missouri, Columbia, Missouri.
Nathan J BivensDNA Core Facility, University of Missouri, Columbia, Missouri.
Scott A GivanBond Life Sciences Center, University of Missouri, Columbia, Missouri givans@missouri.edu rosenfeldc@missouri.edu.
Cheryl S RosenfeldBond Life Sciences Center, University of Missouri, Columbia, Missouri givans@missouri.edu rosenfeldc@missouri.edu.
University of Missouri · US

Funding

Endocrine Disrupting Chemicals, Epigenetic Alterations, and Autism-Like Behaviors in the Highly Social California Mouse ModelR01ES025547 · NIEHS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROBERTS, R. MICHAEL · 2016 to 2020
$1.9M
NIEHS NIH HHS R01 ES025547
6 · The paper itself

Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) prevalent in many household items. Rodent models and human epidemiological studies have linked this chemical to neurobehavior impairments. In California mice, developmental exposure to BPA results in sociosexual disorders at adulthood, including communication and biparental care deficits, behaviors that are primarily regulated by the hypothalamus. Thus, we sought to examine the transcriptomic profile in this brain region of juvenile male and female California mice offspring exposed from periconception through lactation to BPA or ethinyl estradiol (EE, estrogen present in birth control pills and considered a positive estrogen control for BPA studies). Two weeks prior to breeding, P

Indexed as

AnimalsBenzhydryl CompoundsBisphenol A CompoundsDown-RegulationEndocrine DisruptorsEthinyl EstradiolFemaleHypothalamusMaleMaternal ExposurePeromyscusPhenolsPregnancyPrenatal Exposure Delayed EffectsTranscriptomeUp-RegulationBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsEthinyl EstradiolPhenolsBrainDOHaDendocrine‐disrupting chemicalsestrogensRNA‐seq

Identifiers

PMID28196854
PMCPMC5309579
OpenAlexW2588504617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.