Trial reportJournal of the American Heart Association2017
Association of Morning Hypertension Subtype With Vascular Target Organ Damage and Central Hemodynamics.
Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02003781 (Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differences of blood pressure measured at clinic versus at home in the morning and in the evening in Europe and Asia: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Perirenal Fat Thickness Is Associated With Disturbed Circadian Blood Pressure Rhythm in Essential Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Nighttime Systolic Blood Pressure Determined by Pulse Transit Time Predicts Cardiac Events in Patients With Heart Failure.Journal of the American Heart Association · 2025Article
- Controversies in hypertension therapy: bedtime dosing or daytime dosing?Journal of hypertension · 2025Review
- The Association of Morning Surge and Night-Time Dipping Blood Pressure with Significant and Complex Coronary Artery Lesions.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Article
- The Association of Morning Hypertension With Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Prevalence and prognosis of the 2018 vs 2008 AHA definitions of apparent treatment-resistant hypertension in high-risk hypertension patients.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Metabolic-related markers and inflammatory factors as predictors of dyslipidemia among urban Han Chinese adults.Lipids in health and disease · 2019Article
- Morning hypertension is a risk factor of macrovascular events following cerebral infarction: A retrospective study.Medicine · 2018Article
- Autonomic nervous system: an integrative regulator in circadian rhythm of blood pressure.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent study reported that morning hypertension is associated with poor cardiovascular outcomes in hypertensive patients. However, it is unclear whether morning hypertension associated with sustained nocturnal hypertension and that associated with morning blood pressure (BP) surge differ in terms of their effects on cardiovascular target organ damage and clinical outcomes. The present study aimed to determine the association of morning hypertension with/without nocturnal hypertension with vascular target organ damage and central hemodynamics in patients at high risk for cardiovascular disease. METHODS AND
resultsAmbulatory BP monitoring was performed and central BP was measured in 1070 consecutive patients with high cardiovascular risk. We grouped morning hypertension into the following 3 subtypes: (I) morning normotension; (II) morning hypertension without nocturnal hypertension; and (III) morning hypertension with nocturnal hypertension. Morning hypertension was noted in 469 (43.8%) patients and morning hypertension with nocturnal hypertension was noted in 374 (34.9%) patients. The central systolic/diastolic BP and carotid to femoral pulse wave velocity were significantly higher in the subtype III group than in the subtype I and II groups (all
conclusionsMorning hypertension, especially that associated with nocturnal hypertension, is related to high central BP and increased arterial stiffness. Further studies on whether morning hypertension with or without nocturnal hypertension is related to clinical outcomes should be performed. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02003781.
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