Evidence map›Paper›PMID 28196689›Full record

ArticleStem cell reports2017

Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

Ilias Kazanis, Kimberley A Evans, Evangelia Andreopoulou, Christina Dimitriou, Christos Koutsakis, Ragnhildur Thora Karadottir, Robin J M Franklin

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Remyelination in the Central Nervous System.Cold Spring Harbor perspectives in biology · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Live imaging of remyelination in the adult mouse corpus callosum.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Review
  18. Myelin Repair: From Animal Models to Humans.Frontiers in cellular neuroscience · 2021
    Review
  19. DCXScientific reports · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ilias KazanisWellcome Trust-MRC Cambridge Stem Cell Biology Institute, University of Cambridge, Cambridge CB2 0AH, UK; Lab of Developmental Biology, Department of Biology, University of Patras, Patras 26500, Greece. Electronic address: ikazanis@upatras.gr.
Kimberley A EvansWellcome Trust-MRC Cambridge Stem Cell Biology Institute, University of Cambridge, Cambridge CB2 0AH, UK.
Evangelia AndreopoulouLab of Developmental Biology, Department of Biology, University of Patras, Patras 26500, Greece.
Christina DimitriouLab of Developmental Biology, Department of Biology, University of Patras, Patras 26500, Greece.
Christos KoutsakisLab of Developmental Biology, Department of Biology, University of Patras, Patras 26500, Greece.
Ragnhildur Thora KaradottirWellcome Trust-MRC Cambridge Stem Cell Biology Institute, University of Cambridge, Cambridge CB2 0AH, UK.
Robin J M FranklinWellcome Trust-MRC Cambridge Stem Cell Biology Institute, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: rjf1000@cam.ac.uk.
University of Patras · GRWellcome/MRC Cambridge Stem Cell Institute · GBUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I013210/1Medical Research Council MC_PC_12009
6 · The paper itself

Abstract

Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche. pOPCs are committed perinatally and retain their numbers through self-renewing divisions, while SEZ-derived cells are relatively "young," being constantly born from neural stem cells. We compared the behavior of these populations, labeling SEZ-derived cells using hGFAP:Cre

Indexed as

Age FactorsAnimalsBiomarkersBrainCell DifferentiationDemyelinating DiseasesDisease Models, AnimalMiceMice, TransgenicMyelin SheathNeurogenesisOligodendrogliaStem Cell NicheBiomarkersageingcorpus callosumdemyelinationmyelinmyelinationneural stem celloligodendroblastoligodendrocyte progenitor cellOPCremyelinationsubependymal zonesubventricular zone

Identifiers

PMID28196689
PMCPMC5355571
OpenAlexW2586559282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.