Evidence map›Paper›PMID 28196590›Full record

ArticleCancer cell2017

Singling Out Chromosome Gains in Tumor Evolution.

Ryan M Naylor, Jan M van Deursen

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ryan M NaylorDepartment of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Jan M van DeursenDepartment of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: vandeursen.jan@mayo.edu.

Funding

BUBRI in Normal and Neoplastic GrowthR01CA096985 · NCI · MAYO CLINIC ROCHESTER · PI BAKER, DARREN · 2002 to 2022
$6.2M
BUB1 in Chromosomal Instability and TumorigenesisR01CA126828 · NCI · MAYO CLINIC ROCHESTER · PI VAN DEURSEN, JAN M. · 2007 to 2016
$2.8M
The Role of Nup88 Overexpression in Cellular Transformation and TumorigenesisF30CA189339 · NCI · MAYO CLINIC ROCHESTER · PI NAYLOR, RYAN M · 2014 to 2017
$165k
NCI NIH HHS F30 CA189339NCI NIH HHS R01 CA096985NCI NIH HHS R01 CA126828
6 · The paper itself

Abstract

In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.

Indexed as

ChromosomesAneuploidyChromosome AberrationsGenomic InstabilityHumansNeoplasms

Identifiers

PMID28196590
PMCPMC5446207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.