ArticleBMC cardiovascular disorders2017
Aortic stiffening precedes onset of heart failure with preserved ejection fraction in patients with asymptomatic diastolic dysfunction.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04395846 (Heart Failure and Preserved Ejection Fraction), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Failure and Preserved Ejection Fraction: Observation of Its Progression and Prognosis (HOPP-BERN)
Who cites it
15 citing papers in PubMed.
- Association of Cardiac MRI-derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction.Radiology. Cardiothoracic imaging · 2024Trial
- Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Interrelationship Between Cardiopulmonary Exercise Testing Indices and Markers of Subclinical Cardiovascular Dysfunction in Those with Type 2 Diabetes-An Observational Cross-Sectional Analysis.Journal of functional morphology and kinesiology · 2025Article
- Inversion of Left Ventricular Axial Shortening: In Silico Proof of Concept for Treatment of HFpEF.Bioengineering (Basel, Switzerland) · 2024Article
- The Stiffness of the Ascending Aorta Has a Direct Impact on Left Ventricular Function: An In Silico Model.Bioengineering (Basel, Switzerland) · 2024Article
- Volumetric brain MRI signatures of heart failure with preserved ejection fraction in the setting of dementia.Magnetic resonance imaging · 2024Article
- Heart Stiffening in Pediatric Dilated Cardiomyopathy: Causes of Severity.The journal of Tehran Heart Center · 2024Article
- Clinical Evidence and Proposed Mechanisms of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Class Effect?Cardiac failure review · 2022Review
- Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction.Heart and vessels · 2021Article
- Association of Midlife Cardiovascular Risk Factors With the Risk of Heart Failure Subtypes Later in Life.Journal of cardiac failure · 2021Article
- Association Between Arterial Stiffness and Heart Failure With Preserved Ejection Fraction.Frontiers in cardiovascular medicine · 2021Article
- Aortic Root Remodeling as an Indicator for Diastolic Dysfunction and Normative Ranges in Asians: Comparison and Validation with Multidetector Computed Tomography.Diagnostics (Basel, Switzerland) · 2020Article
- Identifying Phenogroups in patients with subclinical diastolic dysfunction using unsupervised statistical learning.BMC cardiovascular disorders · 2020Article
- Cranial Irradiation in Childhood Acute Lymphoblastic Leukemia Is Related to Subclinical Left Ventricular Dysfunction and Reduced Large Artery Compliance in Cancer Survivors.Journal of clinical medicine · 2019Article
- Exercise, Arterial Crosstalk-Modulation, and Inflammation in an Aging Population: The ExAMIN AGE Study.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundIdentifying which patients with diastolic dysfunction will progress to heart failure with preserved ejection fraction (HFpEF) remains challenging. The goal of this study is to determine whether increased vascular stiffness as identified on 2D transthoracic echocardiography (TTE) serves as a biomarker for the development of HFpEF in patients with diastolic dysfunction.
methodsThe study design is a matched retrospective case-control study. Subjects with diastolic dysfunction were divided into two groups based on whether they had a clinical diagnosis of HFpEF. The two groups were matched based on age, gender, race and body surface area, resulting in 77 matched pairs (n = 154). Data from the first TTE that documented diastolic dysfunction prior to the development of HFpEF was extracted along with baseline demographic and clinical data. Indices of vascular stiffness were measured and compared. A sub-group analysis was performed to compare diabetic subjects in Group 1 (n = 43) to those in Group 2 (n = 21).
resultsGroup 1 had significantly decreased aortic distensibility as measured on the initial TTE when compared to Group 2 (1.9 ± 1.0 vs. 2.8 ± 1.8 cm
conclusionsThis study demonstrates that increased proximal aortic stiffness is associated with the development of HFpEF in patients with asymptomatic diastolic dysfunction. Larger prospective studies are needed to further investigate this relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.