Evidence map›Paper›PMID 28196432›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2017

Association of seven renin angiotensin system gene polymorphisms with restenosis in patients following coronary stenting.

Min Zhu, Minjun Yang, Jiangbo Lin, Huanhuan Zhu, Yifei Lu, Bing Wang, Yinshen Xue, Congfeng Fang, Lijiang Tang, Baohui Xu and 2 more

Open access · hybridAbstract read
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Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Min Zhu1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Minjun Yang1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Jiangbo Lin1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Huanhuan Zhu1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Yifei Lu1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Bing Wang1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Yinshen Xue1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Congfeng Fang1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Lijiang Tang1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Baohui Xu4 Department of Surgery, Stanford University School of Medicine, USA.
Jianjun Jiang1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Xiaofeng Chen1 Laboratory of Cardiovascular Disease, Taizhou Hospital, Wenzhou Medical University, China.
Wenzhou Medical University · CNStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivePercutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. The renin-angiotensin system is involved in neointimal hyperplasia. This study sought to evaluate seven gene polymorphisms of key renin-angiotensin system components, including angiotensinogen, angiotensin-converting enzyme and angiotensin II type 1a receptors, and their associations with in-stent restenosis in patients with coronary artery disease following coronary stenting. METHODS AND

resultsThree hundred and fifty-two patients undergoing coronary drug-eluting stent implantation were recruited. Seventy-five patients (21.3%) were diagnosed as restenosis by angiography. Genotyping for angiotensin-converting enzyme insertion/deletion demonstrated a significant association of angiotensin-converting enzyme DD genotype with the occurrence of restenosis. Direct DNA sequencing revealed no association of angiotensinogen (M235T, G217A, G152A, G-6A, and A-20C) or angiotensin II type I receptor A1166C polymorphisms with in-stent restenosis. However, angiotensin II type 1a A1166C polymorphism was significantly associated with increased susceptibility to restenosis in a subgroup of patients aged more than 60 years.

conclusionThus, our study suggests that genetic polymorphisms of angiotensin-converting enzyme insertion/deletion are associated with in-stent restenosis in coronary artery disease patients following coronary stenting.

Indexed as

Genetic Association StudiesPolymorphism, GeneticStentsAgedAngiotensinogenBase SequenceCoronary RestenosisFemaleGene FrequencyHumansLinkage DisequilibriumMaleMiddle AgedPeptidyl-Dipeptidase APolymorphism, Single NucleotideReceptor, Angiotensin, Type 1AngiotensinogenPeptidyl-Dipeptidase AReceptor, Angiotensin, Type 1Coronary artery diseaserenin angiotensin systemrestenosissingle nucleotide polymorphism

Identifiers

PMID28196432
PMCPMC5843879
OpenAlexW2588094567

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.