Observational studyThe primary care companion for CNS disorders2017
Executive Functioning at Baseline Prospectively Predicts Depression Treatment Response.
Observational study in The primary care companion for CNS disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of working memory training on depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.Translational psychiatry · 2026Pooled it
- Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression.Translational psychiatry · 2024Trial
- Development of a baseline battery to optimize depression treatment assignment in primary care: Balancing breadth and brevity.Journal of affective disorders · 2026Article
- Transdiagnostic Attentional Deficits Are Associated with Depressive and Externalizing Symptoms in Children and Adolescents with Neuropsychiatric Disorders.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression.Molecular psychiatry · 2024Article
- Participants Attrition in a Longitudinal Study: The Malaysian Cohort Study Experience.International journal of environmental research and public health · 2021Article
- A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression.Neuropsychology review · 2020Review
- Effects of mood and aging on keystroke dynamics metadata and their diurnal patterns in a large open-science sample: A BiAffect iOS study.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Childhood maltreatment, neuropsychological function and suicidal behavior.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Cognitive Control as a 5-HTFrontiers in psychology · 2019Article
- Toward clinical digital phenotyping: a timely opportunity to consider purpose, quality, and safety.NPJ digital medicine · 2019Review
- Predictors of Attrition in Longitudinal Neuroimaging Research: Inhibitory Control, Head Movement, and Resting-State Functional Connectivity.Brain connectivity · 2018Article
- Cognitive control and network disruption in remitted depression: a correlate of childhood adversity.Social cognitive and affective neuroscience · 2018Article
- Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder.Journal of affective disorders · 2018Article
- Differences in the cognitive profile of depression between racial groups.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2018Article
- Cognitive control neuroimaging measures differentiate between those with and without future recurrence of depression.NeuroImage. Clinical · 2018Article
- Association of self-reported executive function and mood with executive function task performance across adult populations.Applied neuropsychology. AdultArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectiveExisting cognitive and clinical predictors of treatment response to date are not of sufficient strength to meaningfully impact treatment decision making and are not readily employed in clinical settings. This study investigated whether clinical and cognitive markers used in a tertiary care clinic could predict response to usual treatment over a period of 4 to 6 months in a sample of 75 depressed adults.
methodsPatients (N = 384) were sequentially tested in 2 half-day clinics as part of a quality improvement project at an outpatient tertiary care center between August 2003 and September 2007; additional subjects evaluated in the clinic between 2007 and 2009 were also included. Diagnosis was according to DSM-IV-TR criteria and completed by residents and attending faculty. Test scores obtained at intake visits on a computerized neuropsychological screening battery were the Parametric Go/No-Go task and Facial Emotion Perception Task. Treatment outcome was assessed using 9-item Patient Health Questionnaire (PHQ-9) self-ratings at follow-up (n = 75). Usual treatment included psychotropic medication and psychotherapy. Decline in PHQ-9 scores was predicted on the basis of baseline PHQ-9 score and education, with neuropsychological variables entered in the second step.
resultsPHQ-9 scores declined by 46% at follow-up (56% responders). Using 2-step multiple regression, baseline PHQ-9 score (P ≤ .05) and education (P ≤ .01) were significant step 1 predictors of percent change in PHQ-9 follow-up scores. In step 2 of the model, faster processing speed with interference resolution (go reaction time) independently explained a significant amount of variance over and above variables in step 1 (12% of variance, P < .01), while other cognitive and affective skills did not. This 2-step model accounted for 28% of the variance in treatment change in PHQ-9 scores. Processing speed with interference resolution also accounted for 12% variance in treatment and follow-up attrition.
conclusionsUse of executive functioning assessments in clinics may help identify individuals with cognitive weaknesses at risk for not responding to standard treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.