Evidence map›Paper›PMID 28196308›Full record

Trial reportJournal of hepato-biliary-pancreatic sciences2017

Risk factors of serious postoperative complications after pancreaticoduodenectomy and risk calculators for predicting postoperative complications: a nationwide study of 17,564 patients in Japan.

Shuichi Aoki, Hiroaki Miyata, Hiroyuki Konno, Mitsukazu Gotoh, Fuyuhiko Motoi, Hiraku Kumamaru, Go Wakabayashi, Yoshihiro Kakeji, Masaki Mori, Yasuyuki Seto and 1 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of hepato-biliary-pancreatic sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07248527 (PAN-ICIS), which is not on this map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07248527 active not recruitingnot on this mapstarted 2025, after this paper: background citation

PAN-ICIS: Prospective Observational Study Evaluating the Intensive Care Infection Score for Early Detection of Infectious Complications After Pancreatic Resections

TypeobservationalSponsorCharles University, Czech RepublicRan2025 to 2028Enrolled400ConditionsPancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. [Clinical Practice and Quality Control Strategies for Complex Minimally Invasive Pancreatic Surgery].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuichi AokiThe Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Hiroaki MiyataThe National Clinical Database, Tokyo, Japan.
Hiroyuki KonnoThe Japanese Society of Gastroenterological Surgery (JSGS) Database Committee, Tokyo, Japan.
Mitsukazu GotohThe National Clinical Database, Tokyo, Japan.
Fuyuhiko MotoiThe Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Hiraku KumamaruThe National Clinical Database, Tokyo, Japan.
Go WakabayashiThe Japanese Society of Gastroenterological Surgery (JSGS) Database Committee, Tokyo, Japan.
Yoshihiro KakejiThe National Clinical Database, Tokyo, Japan.
Masaki MoriThe Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Yasuyuki SetoThe Japanese Society of Gastroenterological Surgery, Tokyo, Japan.
Michiaki UnnoThe Japanese Society of Gastroenterological Surgery (JSGS) Database Committee, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe morbidity rate after pancreaticoduodenectomy remains high. The objectives of this retrospective cohort study were to clarify the risk factors associated with serious morbidity (Clavien-Dindo classification grades IV-V), and create complication risk calculators using the Japanese National Clinical Database.

methodsBetween 2011 and 2012, data from 17,564 patients who underwent pancreaticoduodenectomy at 1,311 institutions in Japan were recorded in this database. The morbidity rate and associated risk factors were analyzed.

resultsThe overall and serious morbidity rates were 41.6% and 4.5%, respectively. A pancreatic fistula (PF) with an International Study Group of Pancreatic Fistula (ISGPF) grade C was significantly associated with serious morbidity (P < 0.001). Twenty-one variables were considered statistically significant predictors of serious complications, and 15 of them overlapped with those of a PF with ISGPF grade C. The predictors included age, sex, obesity, functional status, smoking status, the presence of a comorbidity, non-pancreatic cancer, combined vascular resection, and several abnormal laboratory results. C-indices of the risk models for serious morbidity and grade C PF were 0.708 and 0.700, respectively.

conclusionsPreventing a PF grade C is important for decreasing the serious morbidity rate and these risk calculations contribute to adequate patient selection.

Indexed as

Population SurveillanceAgedFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedMorbidityPancreatic NeoplasmsPancreaticoduodenectomyPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsPancreaticoduodenectomyPostoperative complicationsRisk calculator

Identifiers

PMID28196308
PMCPMC5516144

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.