ArticlePloS one2017
Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Essential Oils as a Source of Anticancer Molecules: Critical Assessment of Current Evidence and Methodological Limitations-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- A First-in-Human Phase 1 Randomized Single and Multiple Ascending Dose Study of RPh201 in Healthy Volunteers.Clinical pharmacology in drug development · 2020Trial
- The Activity of Phytotherapic Extracts Combined in a Unique Formulation Alleviates Oxidative Stress and Protects Mitochondria Against Atorvastatin-Induced Cardiomyopathy.International journal of molecular sciences · 2025Article
- Morphological Characterization, Polyphenolic Profile, and Bioactive Properties ofBiomolecules · 2024Article
- Article
- Chemical Composition, In Vitro Antitumor Effect, and Toxicity in Zebrafish of the Essential Oil fromBiomolecules · 2023Article
- In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Antimicrobial Efficiency ofMicroorganisms · 2023Review
- Natural essential oils as a new therapeutic tool in colorectal cancer.Cancer cell international · 2022Review
- A microplate-based DCFH-DA assay for the evaluation of oxidative stress in whole semen.Heliyon · 2022Article
- Why Should Pistachio Be a Regular Food in Our Diet?Nutrients · 2022Review
- Chemical composition, anticancer and antibacterial activity of Nepeta mahanensis essential oil.BMC complementary medicine and therapies · 2022Article
- Effects of sub-acute co-exposure to WIFI (2.45 GHz) and Pistacia lentiscus oil treatment on wound healing by primary intention in male rabbits.Veterinary medicine and science · 2022Article
- Synthesis and Biological Characterization of the New Glycolipid Lactose Undecylenate (URB1418).Pharmaceuticals (Basel, Switzerland) · 2022Article
- Smart Tree: An Architectural, Greening and ICT Multidisciplinary Approach to Smart Campus Environments.Sensors (Basel, Switzerland) · 2021Article
- Leaves and Fruits Preparations ofAntibiotics (Basel, Switzerland) · 2021Review
- Phytochemical Characterization and Effects on Cell Proliferation of Lentisk (Pistacia lentiscus) Berry Oil: a Revalued Source of Phenolics.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Synthesis of new dihydroberberine and tetrahydroberberine analogues and evaluation of their antiproliferative activity on NCI-H1975 cells.Beilstein journal of organic chemistry · 2020Article
- Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan.Medicines (Basel, Switzerland) · 2019Review
- Effects of uric acid on vascular endothelial function from bedside to bench.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEssential oils from the aerial parts (leaves, twigs and berries) of Pistacia lentiscus (PLEO) have been well characterized for their antibacterial and anti-inflammatory properties; however, poor information exists on their potential anticancer activity.
methodsIncreasing concentrations of PLEO (0.01-0.1% v/v, 80-800 μg/ml) were administered to a wide variety of cultured cancer cells from breast, cervix, colon, liver, lung, prostate, and thyroid carcinomas. Fibroblasts were also included as healthy control cells. Cell viability was monitored by WST-8 assay up to 72 hours after PLEO administration. The intracellular formation of reactive oxygen species (ROS), the induction of apoptosis, and the enhancement of chemotherapeutic drug cytotoxicity by PLEO were further investigated in the most responsive cancer cell line.
resultsA dose-dependent reduction of tumor cell viability was observed upon PLEO exposure; while no cytotoxic effect was revealed in healthy fibroblasts. FTC-133 thyroid cancer cells were found to be the most sensitive cells to PLEO treatment; accordingly, an intracellular accumulation of ROS and an activation of both the extrinsic and intrinsic apoptotic pathways were evidenced in FTC-133 cells after PLEO administration. Furthermore, the cytotoxic effect of the antineoplastic drugs cisplatin, 5-fluorouracil and etoposide was enhanced in PLEO-exposed FTC-133 cells.
conclusionTaking into account its mode of action, PLEO might be considered as a promising source of natural antitumor agents which might have therapeutic potential in integrated oncology.
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