ArticleJournal of perinatal medicine2017
B-type natriuretic peptide and echocardiography reflect volume changes during pregnancy.
Article in Journal of perinatal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Cardiac Biomarkers and Pregnancy-Associated Cardiovascular Disease.Current cardiology reports · 2026Review
- BNP-Derived Uric Acid Composite Indices for the Evaluation of Dyspnea in Third-Trimester Pregnancy: A Prospective Emergency Department Study.Journal of clinical medicine · 2026Article
- Bridging the Gap Between Genetic Cardiomyopathies and Pregnancy.JACC. Advances · 2026Article
- Left Atrial Volumes and Strains in Healthy Mid-Term Pregnancy-A Detailed Investigation from a Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Preg Study.Biomedicines · 2026Article
- Maternal heart failure: state-of-the-art review.Heart failure reviews · 2025Review
- Impact of High-Risk Pregnancy on Peripartum Left Ventricular Function.Circulation reports · 2025Article
- Variations in NT-proBNP Levels in Pregnant Patients with and without SARS-CoV-2 Infection: Consequences for the Newborns.Biomedicines · 2023Article
- Prospective Observational Study of N-terminal Pro-Brain Natriuretic Peptide Levels in Obese and Nonobese Women during Pregnancy.American journal of perinatology · 2023Observational
- Prevalence and Correlates of Elevated NT-proBNP in Pregnant Women in the General U.S. Population.JACC. Advances · 2023Article
- Review
- The Utilization and Interpretation of Cardiac Biomarkers During Pregnancy:JACC. Advances · 2022Review
- Postpartum preeclampsia or eclampsia: defining its place and management among the hypertensive disorders of pregnancy.American journal of obstetrics and gynecology · 2022Review
- Early N-Terminal Pro B-Type Natriuretic Peptide (NTproBNP) Plasma Values and Associations with Patent Ductus Arteriosus Closure and Treatment-An Echocardiography Study of Extremely Preterm Infants.Journal of clinical medicine · 2022Article
- Interconception Care for Primary Care Providers: Consensus Recommendations on Preconception and Postpartum Management of Reproductive-Age Patients With Medical Comorbidities.Mayo Clinic proceedings. Innovations, quality & outcomes · 2021Review
- Pregnancy-specific Reference Intervals for BNP and NT-pro BNP-Changes in Natriuretic Peptides Related to Pregnancy.Journal of the Endocrine Society · 2021Article
- Maternal plasma pro-atrial and C-type natriuretic peptide levels and their associations with cardiovascular and renal function in the second half of normal pregnancy: a longitudinal study.BMC pregnancy and childbirth · 2021Article
- Morphofunctional cardiac changes in singleton and twin pregnancies: a longitudinal cohort study.BMC pregnancy and childbirth · 2020Article
- Observational
- Thoracic ultrasound evaluation and B-type natriuretic peptide value in elective cesarean section under spinal anesthesia.The ultrasound journal · 2020Article
- Brain natriuretic peptide in pregnant women with heart disease.Obstetric medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac structure and function in normal women through pregnancy and the postpartum.
methodsIn this prospective observational study, we obtained serial transthoracic echocardiograms, BNP, and NT-proBNP at seven intervals from 6 weeks' gestation through 12 months postpartum. Women with hypertension or cardiac disease were excluded. Using 6-12 months postpartum as reference for non-pregnant levels, echocardiogram measurements and BNP/NT-proBNP were compared over time using linear mixed models with Tukey-Kramer adjustment for multiple comparisons.
resultsOf 116 patients, data was available for 78-114 healthy pregnant or postpartum women within each time interval, and 102 patients provided data for ≥4 intervals. Compared to 6-12 months postpartum, BNP and NT-proBNP remained stable through pregnancy and delivery, increased within 48 h postpartum (P<0.0001), then returned to baseline. Left ventricular volume increased within 48 h postpartum (P=0.021) while left atrial volume increased at 18-24 weeks (P=0.0002), 30-36 weeks (P<0.0001) and within 48 h postpartum (P=0.002). The transmitral early/late diastolic velocity (E/A) ratio, transmitral early/peak mitral annulus diastolic velocity (E/E') ratio, isovolumic relaxation times, and mitral valve deceleration times were similar within 48 h and 6-12 months postpartum.
conclusionIn normal women, BNP/NT-proBNP, left atrial, and left ventricular volumes increase within 48 h postpartum without indications of altered diastolic function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.