ArticleJournal of clinical laboratory analysis2017
Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Dietary Intervention during 9 Months with a Hypocaloric Diet, Interaction of the Genetic Variant of Adiponectin Gene rs822393 with Metabolic Parameters.Disease markers · 2022Trial
- Genetic Variant in Leptin rs7799039 Is Associated with Total Body Mineral Estimates, but Not with Fat Mass, in Young Healthy Adults.Nutrients · 2026Article
- Variants of Visceral Adipocytokine Genes in Obesity and Coronary Atherosclerosis: A Review.Current medicinal chemistry · 2026Review
- The Role of Adiponectin andGenes · 2025Review
- Resistin in cardiac diseases: from molecular mechanisms to clinical implications.Frontiers in endocrinology · 2025Review
- Association ofIranian journal of public health · 2024Review
- Article
- Dissecting the Molecular Role ofBiomedicines · 2023Article
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Heterogeneity in biomarkers, mitogenome and genetic disorders of the Arab population with special emphasis on large-scale whole-exome sequencing.Archives of medical science : AMS · 2023Article
- Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome.Journal of diabetes research · 2022Article
- Genetics, genomics, and diet interactions in obesity in the Latin American environment.Frontiers in nutrition · 2022Review
- Association of ADIPOQ-rs2241766 and FTO-rs9939609 genetic variants with body mass index trajectory in women of reproductive age over 6 years of follow-up: the PREDI study.European journal of clinical nutrition · 2022Article
- Associations ofGenes · 2021Article
- Is Single Nucleotide PolymorphismPathology oncology research : POR · 2021Article
- Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females.International journal of general medicine · 2020Article
- Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos.Medicina (Kaunas, Lithuania) · 2019Article
- The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome.BMC women's health · 2019Article
- Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity.BioMed research international · 2019Article
- Resistin polymorphims, plasma resistin levels and obesity in Tunisian volunteers.Journal of clinical laboratory analysis · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue is an important endocrine organ that secretes a number of adipokines, such as adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR), and resistin (RETN) which may be implicated in obesity. Some adipokines' polymorphisms of genes might influence their concentrations and/or activities. Our aim was to study the relationship between seven SNPs in ADIPOQ (+45T<G (rs2241766); +276G<T (rs1501299); -4255C<T (rs822393); -395G<T (rs17366568)), LEP (2548G<A (rs7799039)), LEPR (223Q<R (rs1137101)), and RETN (-420C<G (rs1862513)) and obesity in Hammam Sousse Sahloul Heart Study (HSHS).
methodsThe study, carried out between February and June 2009, is mainly focused on 1121 respondents in HSHS which is a population-based epidemiological study of type "community-based" on cardiovascular risk. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum lipids and anthropometric parameters were measured. Statistic analysis was performed on SPSSv19.
resultsThe polymorphisms of ADIPOQ 4522C<T and 276G<T, LEP 2548G<A, and RETN 420C<G seem to contribute to obesity. In fact, adjusted odds ratios (ORs) of obesity associated with mutated genotypes of each polymorphism were respectively OR=1.38, P=.037; OR=0.608, P<.001; OR=2.23, P=.034; and OR=2.18, P<.001. The 276G<T, 4522C<T, and 420C<G were associated with increased BMI (P=.010, P=.028, and P<.001). A significant association was found between the 276G<T; 4522C<T, LEP 2548G<A and 420C<G, and the waist circumference and hip measurements.
conclusionADIPOQ, LEP, and RETN gene polymorphisms were associated with obesity parameters in HSHS population.
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