ArticleEvolution; international journal of organic evolution2017
Ploidy tug-of-war: Evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- FKS1/2-variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infections.Nature communications · 2026Article
- Experimental Evolution of PathogenicMicroorganisms · 2026Review
- Patterns and mechanisms of fungal genome plasticity.Current biology : CB · 2025Review
- Development of a RobustMicroorganisms · 2024Article
- Ploidy evolution in a wild yeast is linked to an interaction between cell type and metabolism.PLoS biology · 2023Article
- Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures.Nature communications · 2023Article
- Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures.Research square · 2023Article
- Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans.Molecular biology and evolution · 2023Article
- Complex genetics cause and constrain fungal persistence in different parts of the mammalian body.Genetics · 2022Article
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- Article
- Tetraploidy accelerates adaptation under drug selection in a fungal pathogen.Frontiers in fungal biology · 2022Article
- Increased Virulence and Large-Scale Reduction in Genome Size of TetraploidFrontiers in fungal biology · 2022Article
- Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris.Antimicrobial agents and chemotherapy · 2020Article
- Virulence phenotypes result from interactions between pathogen ploidy and genetic background.Ecology and evolution · 2020Article
- Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs.eLife · 2020Article
- Article
- Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.mSphere · 2020Article
- Short-term evolution strategies for host adaptation and drug escape in human fungal pathogens.PLoS pathogens · 2020Review
- Advances in understanding the evolution of fungal genome architecture.F1000Research · 2020Review
Corrections and comments
- Erratum issuedERRATUM.2017
Authors and funding
4 authors.
Funding
Abstract
Variation in baseline ploidy is seen throughout the tree of life, yet the factors that determine why one ploidy level is maintained over another remain poorly understood. Experimental evolution studies using asexual fungal microbes with manipulated ploidy levels intriguingly reveals a propensity to return to the historical baseline ploidy, a phenomenon that we term "ploidy drive." We evolved haploid, diploid, and polyploid strains of the human fungal pathogen Candida albicans under three different nutrient limitation environments to test whether these conditions, hypothesized to select for low ploidy levels, could counteract ploidy drive. Strains generally maintained or acquired smaller genome sizes (measured as total nuclear DNA through flow cytometry) in minimal medium and under phosphorus depletion compared to in a complete medium, while mostly maintained or acquired increased genome sizes under nitrogen depletion. Improvements in fitness often ran counter to changes in genome size; in a number of scenarios lines that maintained their original genome size often increased in fitness more than lines that converged toward diploidy (the baseline ploidy of C. albicans). Combined, this work demonstrates a role for both the environment and genotype in determination of the rate of ploidy drive, and highlights questions that remain about the force(s) that cause genome size variation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.