ArticleScientific reports2017
Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular mechanisms of Eda-mediated adaptation to freshwater in threespine stickleback.Molecular ecology · 2025Article
- Evolutionary balance between genomic conservation and coral reef adaptation in the yellow boxfish (Zoological research · 2025Article
- Review
- Genome-wide species delimitation analyses of a silverside fish species complex in central Mexico indicate taxonomic over-splitting.BMC ecology and evolution · 2022Article
- Prior exposure to long-day photoperiods alters immune responses and increases susceptibility to parasitic infection in stickleback.Proceedings. Biological sciences · 2020Article
- A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus).Molecular ecology · 2018Article
- Contemporary ancestor? Adaptive divergence from standing genetic variation in Pacific marine threespine stickleback.BMC evolutionary biology · 2018Article
- Ongoing niche differentiation under high gene flow in a polymorphic brackish water threespine stickleback (Gasterosteus aculeatus) population.BMC evolutionary biology · 2018Article
- Investigating the association between armour coverage and parasite infection in an estuarine population of stickleback.Evolutionary ecology researchArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haplotypes underlying local adaptation and speciation are predicted to have numerous phenotypic effects, but few genes involved have been identified, with much work to date concentrating on visible, morphological, phenotypes. The link between genes controlling these adaptive morphological phenotypes and the immune system has seldom been investigated, even though changes in the immune system could have profound adaptive consequences. The Eda gene in three-spined stickleback is one of the best studied major adaptation genes; it directly controls bony plate architecture and has been associated with additional aspects of adaptation to freshwater. Here, we exposed F2 hybrids, used to separate Eda genotype from genetic background, to contrasting conditions in semi-natural enclosures. We demonstrate an association between the Eda haplotype block and the expression pattern of key immune system genes. Furthermore, low plated fish grew less and experienced higher burdens of a common ectoparasite with fitness consequences. Little is currently known about the role of the immune system in facilitating adaptation to novel environments, but this study provides an indication of its potential importance.
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