ArticleNature communications2017
A genome-wide association study yields five novel thyroid cancer risk loci.
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In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 10 of them syntheses that pooled it.
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102citing papers in PubMed, 10 pooled it
13.7field-weighted citation impact, top 1% of its field
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Who cites it
102 citing papers in PubMed, 10 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.Nature genetics · 2026Pooled it
- Association between infertility and thyroid cancer risk: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.Nature communications · 2025Pooled it
- Association of telomerase reverse transcriptase gene rs10069690 variant with cancer risk: an updated meta-analysis.BMC cancer · 2024Pooled it
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.Nature communications · 2024Pooled it
- Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2023Pooled it
- Investigating the Association Between rs2439302 Polymorphism and Thyroid Cancer: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
- TERT rs10069690 polymorphism and cancers risk: A meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.Nature communications · 2018Pooled it
- Gene network and biological pathways associated with susceptibility to differentiated thyroid carcinoma.Scientific reports · 2021Trial
- Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis.EBioMedicine · 2026Article
- Article
- Ingested nitrate and nitrite, drinking water disinfection by-products, and incidence of thyroid cancer among licensed pesticide applicators and spouses in the Agricultural Health Study.Ecotoxicology and environmental safety · 2026Article
- Meta single-cell atlas and xQTL post-GWAS analysis revealed the pathogenic features of thyroid cancer for target therapy: A multi-omics study.Cancer gene therapy · 2026Article
- Review
- Cross-tissue transcriptome-wide analysis reveals novel insights into thyroid cancer etiology.Discover oncology · 2025Article
- Single-Nucleotide Polymorphisms of BRCA1 and BRCA2 and Risk of Papillary Thyroid Carcinoma.Cancers · 2025Article
- Assessment of causal association between autoimmune thyroiditis and thyroid cancer: A Mendelian randomization study.Medicine · 2025Article
- Polygenic Score for Clinicopathologic Features and Survival Outcomes in Papillary Thyroid Carcinoma.JAMA otolaryngology-- head & neck surgery · 2025Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
40 authors at 13 institutions in 4 countries.
Julius GudmundssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Gudmar ThorleifssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Jon K SigurdssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Lilja StefansdottirdeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Jon G JonassonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Sigurjon A GudjonssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Daniel F GudbjartssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Gisli MassondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Hrefna JohannsdottirdeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Gisli H HalldorssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Simon N StaceydeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Hannes HelgasondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Patrick SulemdeCODE genetics/AMGEN, 101 Reykjavik, Iceland.ORCID 0000-0001-7123-6123
Leigha SenterDivision of Human Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.
Huiling HeDepartment of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.
Sandya LiyanarachchiDepartment of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.
Matthew D RingelDivision of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.
Esperanza AguilloDivision of Endocrinology, University Hospital, 50009 Zaragoza, Spain.
Angeles PanaderoDivision of Medical Oncology, Ciudad de Coria Hospital, 10800 Coria, Spain.
Enrique PratsDivision of Nuclear Medicine, University Hospital, 50009 Zaragoza, Spain.
Almudena Garcia-CastañoDivision of Medical Oncology, Marques de Valdecilla University Hospital, 39008 Santander, Spain.
Ana De JuanDivision of Medical Oncology, Marques de Valdecilla University Hospital, 39008 Santander, Spain.
Fernando RiveraDivision of Medical Oncology, Marques de Valdecilla University Hospital, 39008 Santander, Spain.
Li XuDepartment of Head &Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Lambertus A KiemeneyRadboud University Medical Centre, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Gudmundur I EyjolfssonThe Laboratory in Mjodd, 109 Reykjavik, Iceland.
Olof SigurdardottirDepartment of Clinical Biochemistry, Akureyri Hospital, 600 Akureyri, Iceland.
Isleifur OlafssonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Hoskuldur KristvinssonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Romana T Netea-MaierDivision of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Radboud Institute for Health Sciences, 6500HB Nijmegen, The Netherlands.
Thorvaldur JonssonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Jose I MayordomoUniversity of Colorado Hospital, Aurora, Colorado 80045, USA.
Theo S PlantingaDepartment of Pathology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6500HB Nijmegen, The Netherlands.
Hannes HjartarsonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Jon HrafnkelssonLandspitali-University Hospital, 101 Reykjavik, Iceland.
Erich M SturgisDepartment of Head &Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Unnur ThorsteinsdottirdeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Thorunn RafnardeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
Albert de la ChapelleDepartment of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.ORCID 0000-0001-9345-9248
Kari StefanssondeCODE genetics/AMGEN, 101 Reykjavik, Iceland.
deCODE Genetics (Iceland) · ISReykjavík University · ISMarqués de Valdecilla University Hospital · ESRadboud University Nijmegen · NLThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe University of Texas MD Anderson Cancer Center · USUniversidad de Zaragoza · ESAkureyri Hospital · ISCancer Genetics (United States) · USHospital General Universitario de Ciudad Real · ESInnovation Center Iceland · ISThe Ohio State University · USUniversity of Colorado Hospital · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MSelective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4MThe Ohio State University and MD Anderson Cancer Center Thyroid Cancer SPOREP50CA168505 · NCI · OHIO STATE UNIVERSITY · PI DE LA CHAPELLE, ALBERT · 2013 to 2017
$10.9MMolecular and Epidemiologic Characterization of Salivary Gland CarcinomasU01DE019765 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI EL-NAGGAR, ADEL K. · 2009 to 2013
$6.9MLIMBIC &MEDULLARY MECH. IN COCAINE-RELATED SUDDEN DEATHR01DA006227 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C. · 1990 to 2012
$3.7MEpigenetic Marks of Cocaine AddictionR01DA033684 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C., TURECKI, GUSTAVO · 2011 to 2015
$3.6MMethods for high-resolution analysis of genetic effects on gene expressionR01MH101814 · NIMH · UNIVERSITY OF GENEVA · PI BUSTAMANTE, CARLOS DANIEL, DERMITZAKIS, EMMANOUIL · 2013 to 2016
$2.3MHarnessing GTEx to Create Transcriptome Knowledge and Inform Disease BiologyR01MH101820 · NIMH · UNIVERSITY OF CHICAGO · PI COX, NANCY J, NICOLAE, DAN LIVIU · 2013 to 2015
$2.3MIdentification and validation of cell specific eQTLs by Bayesian modelingR01MH101822 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BROWN, CHRISTOPHER DAVID, ENGELHARDT, BARBARA · 2013 to 2016
$1.9MGenetic Regulation of Gene Expression and its Impact on Phenotypes - SupplementR01MH101782 · NIMH · STANFORD UNIVERSITY · PI SABATTI, CHIARA · 2013 to 2016
$1.3MMODELING THE EFFECTS OF STRUCTURAL VARIATION IN GTEX DATA AND MENDELIAN DISEASER01MH101810 · NIMH · WASHINGTON UNIVERSITY · PI CONRAD, DONALD F. · 2013 to 2016
$1.3MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS P01 CA124570NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA168505NHLBI NIH HHS HHSN268201000029CNIDA NIH HHS R01 DA006227NIDA NIH HHS R01 DA033684NIDCR NIH HHS U01 DE019765NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825
Abstract
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P
Indexed as
Genetic LociGenome-Wide Association StudyAdultAsian PeopleCarcinoma, PapillaryCase-Control StudiesChromosomes, HumanFemaleGene Expression Regulation, NeoplasticGene FrequencyGenetic Predisposition to DiseaseGenomic Structural VariationGenotypeHumansMaleMiddle AgedPituitary Hormones
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