ArticleeLife2017
Generalizable knowledge outweighs incidental details in prefrontal ensemble code over time.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- An abstract relational map emerges in the human medial prefrontal cortex with consolidation.Current biology : CB · 2026Article
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- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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- Organizing the coactivity structure of the hippocampus from robust to flexible memory.Science (New York, N.Y.) · 2024Article
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- Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.Frontiers in aging neuroscience · 2023Article
- Human brain activity and functional connectivity as memories age from one hour to one month.Cognitive neuroscience · 2022Article
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- Lateral Entorhinal Cortex Suppresses Drift in Cortical Memory Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Prefrontal Neural Ensembles Develop Selective Code for Stimulus Associations within Minutes of Novel Experiences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex.Journal of neurophysiology · 2020Article
- Coincident Pre- and Post-Synaptic Cortical Remodelling Disengages Episodic Memory from Its Original Context.Molecular neurobiology · 2019Article
- Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.Neurobiology of aging · 2018Article
- The role of engram cells in the systems consolidation of memory.Nature reviews. Neuroscience · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memories for recent experiences are rich in incidental detail, but with time the brain is thought to extract latent rules and structures common across past experiences. We show that over weeks following the acquisition of two distinct associative memories, neuron firing in the rat prelimbic prefrontal cortex (mPFC) became less selective for perceptual features unique to each association and, with an apparently different time-course, became more selective for common relational features. We further found that during exposure to a novel experimental context, memory expression and neuron selectivity for relational features immediately generalized to the new situation. These neural patterns offer a window into the network-level processes by which the mPFC develops a knowledge structure of the world that can be adaptively applied to new experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.