ArticleMicrobial biotechnology2017
Ethanol production by the hyperthermophilic archaeon Pyrococcus furiosus by expression of bacterial bifunctional alcohol dehydrogenases.
Article in Microbial biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Sulfolobales: Acidothermophilic archaea as models for biology and biotechnological applications.Engineering microbiology · 2026Review
- Iron-Containing Alcohol Dehydrogenase from Hyperthermophiles.Biotech (Basel (Switzerland)) · 2026Review
- A pH-dependent shift of redox cofactor specificity in a benzyl alcohol dehydrogenase of aromatoleum aromaticum EbN1.Applied microbiology and biotechnology · 2024Article
- Manipulating Fermentation Pathways in the Hyperthermophilic ArchaeonApplied and environmental microbiology · 2023Article
- Improving tyrosol production efficiency through shortening the allosteric signal transmission distance of pyruvate decarboxylase.Applied microbiology and biotechnology · 2023Article
- Characterization ofBiology · 2022Article
- Study on the Effect of Key GenesFoods (Basel, Switzerland) · 2022Article
- A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 °C.Scientific reports · 2021Article
- Advances in the Detection of Dithiocarbamate Fungicides: Opportunities for Biosensors.Biosensors · 2020Review
- Engineering the cellulolytic extreme thermophile Caldicellulosiruptor bescii to reduce carboxylic acids to alcohols using plant biomass as the energy source.Journal of industrial microbiology & biotechnology · 2020Article
- Integration of large heterologous DNA fragments into the genome of Thermococcus kodakarensis.Extremophiles : life under extreme conditions · 2020Article
- Wetland Sediments Host Diverse Microbial Taxa Capable of Cycling Alcohols.Applied and environmental microbiology · 2019Article
- Characterization of an Aldehyde Oxidoreductase From the Mesophilic BacteriumFrontiers in microbiology · 2019Article
- Engineering redox-balanced ethanol production in the cellulolytic and extremely thermophilic bacterium,Metabolic engineering communications · 2018Article
- 'Pyrococcus furiosus, 30 years on'.Microbial biotechnology · 2017Article
- Ethanol production by the hyperthermophilic archaeon Pyrococcus furiosus by expression of bacterial bifunctional alcohol dehydrogenases.Microbial biotechnology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethanol is an important target for the renewable production of liquid transportation fuels. It can be produced biologically from pyruvate, via pyruvate decarboxylase, or from acetyl-CoA, by alcohol dehydrogenase E (AdhE). Thermophilic bacteria utilize AdhE, which is a bifunctional enzyme that contains both acetaldehyde dehydrogenase and alcohol dehydrogenase activities. Many of these organisms also contain a separate alcohol dehydrogenase (AdhA) that generates ethanol from acetaldehyde, although the role of AdhA in ethanol production is typically not clear. As acetyl-CoA is a key central metabolite that can be generated from a wide range of substrates, AdhE can serve as a single gene fuel module to produce ethanol through primary metabolic pathways. The focus here is on the hyperthermophilic archaeon Pyrococcus furiosus, which grows by fermenting sugar to acetate, CO
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