ArticleJournal of child psychology and psychiatry, and allied disciplines2017
Commentary: What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017).
Article in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.GeroScience · 2026Article
- Independent, Multiplicative, and Cumulative Effects of Recent Stressful Life Events and Adverse Childhood Events on Depressive Symptoms among College Students: Moderation by the HPA-axis Multilocus Genetic Variation.Journal of youth and adolescence · 2025Article
- Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth.Epidemiology and psychiatric sciences · 2024Article
- Single Nucleotide Polymorphisms WithinCurrent addiction reports · 2024Article
- Genetic and Epigenetic Association ofInternational journal of molecular sciences · 2024Article
- The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?International journal of molecular sciences · 2024Review
- Molecular signatures of attention networks.Human brain mapping · 2024Article
- Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery.Biomolecules · 2024Review
- Preliminary Evidence That the Short Allele of 5-HTTLPR Moderates the Association of Psychiatric Symptom Severity on Suicide Attempt: The Example in Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2022Article
- Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation.Translational psychiatry · 2021Article
- Article
- Genome Wide Prediction, Mapping and Development of Genomic Resources of Mastitis Associated Genes in Water Buffalo.Frontiers in veterinary science · 2021Article
- The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia.Brain sciences · 2020Article
- Reply to Lyon et al.: Self-regulation and theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.The American journal of psychiatry · 2019Article
- Romantic Partner Alcohol Misuse Interacts withJournal of contemporary criminal justice · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Border and Keller argue that candidate gene approaches are outdated and out-of-touch with the current understanding of the genetic architecture of complex behavioral traits and should be abandoned in favor of unbiased, genome-wide approaches. Border and Keller further suggest that a candidate gene should not be selected for in-depth investigation unless identified by a well-powered genome-wide association study (GWAS). An alternative perspective is offered that candidate approaches can be sensible for developmental and deep-phenotyping studies aimed at elucidating particular biological pathways responsible for the emergence of psychological phenotypes, and that candidates should not necessarily be expected to be confirmed by, or solely selected based on, GWAS. Both candidate and whole genome strategies have limitations, and each approach is useful and valid in the quest to identify the elusive genetic architecture of complex behavioral phenotypes.
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