ArticleJournal of the American Society for Mass Spectrometry2017
Fischer Indole Synthesis in the Gas Phase, the Solution Phase, and at the Electrospray Droplet Interface.
Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- DFT and Mass Spectrometry Study of (-)ESI-Induced Fragmentation of the Highly Toxic Rodenticide Tetramethylenedisulfotetramine.ACS omega · 2026Article
- Ester Formation in Alcohol Microdroplet Sprays: Enhanced Reactivity of CThe journal of physical chemistry. A · 2025Article
- Mechanisms of ionization and of chemical reactions in charged microdroplets.Chemical science · 2025Review
- pH jump kinetics in colliding microdroplets: accelerated synthesis of azamonardine from dopamine and resorcinol.Chemical science · 2023Article
- Spatial reorganization of analytes in charged aqueous microdroplets.Chemical science · 2022Article
- Accelerated synthesis of energetic precursor cage compounds using confined volume systems.Scientific reports · 2021Article
- A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets.Chemical science · 2020Article
- Molecular reactions at aqueous interfaces.Nature reviews. Chemistry · 2020Review
- Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids.Chemical science · 2020Article
- Screening of the Suzuki Cross-Coupling Reaction Using Desorption Electrospray Ionization in High-Throughput and in Leidenfrost Droplet Experiments.Journal of the American Society for Mass Spectrometry · 2019Article
- A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS.Chemical science · 2019Article
- Studying Chemistry in Micro-compartments by Separating Droplet Generation from Ionization.Journal of the American Society for Mass Spectrometry · 2019Article
- A Mass Spectrometer in Every Fume Hood.Journal of the American Society for Mass Spectrometry · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous reports have shown that reactions occurring in the microdroplets formed during electrospray ionization can, under the right conditions, exhibit significantly greater rates than the corresponding bulk solution-phase reactions. The observed acceleration under electrospray ionization could result from a solution-phase, a gas-phase, or an interfacial reaction. This study shows that a gas-phase ion/molecule (or ion/ion) reaction is not responsible for the observed rate enhancement in the particular case of the Fischer indole synthesis. The results show that the accelerated reaction proceeds in the microdroplets, and evidence is provided that an interfacial process is involved. Graphical Abstract <!-- [INSERT GRAPHICAL ABSTRACT TEXT HERE] -->.
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