Evidence map›Paper›PMID 28194735›Full record

ArticleJournal of the American Society for Mass Spectrometry2017

Assigning Peptide Disulfide Linkage Pattern Among Regio-Isomers via Methoxy Addition to Disulfide and Tandem Mass Spectrometry.

Kirt L Durand, Lei Tan, Craig A Stinson, Chasity B Love-Nkansah, Xiaoxiao Ma, Yu Xia

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Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kirt L DurandDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA.
Lei TanDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA.
Craig A StinsonDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA.
Chasity B Love-NkansahDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA.
Xiaoxiao MaDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA.
Yu XiaDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907-2084, USA. yxia@purdue.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pinpointing disulfide linkage pattern is critical in the characterization of proteins and peptides consisting of multiple disulfide bonds. Herein, we report a method based on coupling online disulfide modification and tandem mass spectrometry (MS/MS) to distinguish peptide disulfide regio-isomers. Such a method relies on a new disulfide bond cleavage reaction in solution, involving methanol as a reactant and 254 nm ultraviolet (UV) irradiation. This reaction leads to selective cleavage of a disulfide bond and formation of sulfenic methyl ester (-SOCH

Indexed as

CysteineDisulfidesInsulinIsomerismPeptidesTandem Mass SpectrometryUltraviolet RaysCysteineDisulfidesInsulinPeptidesCollision-induced dissociationDisulfide linkageDisulfide peptidesSulfenic methyl esterUV Photolysis

Identifiers

PMID28194735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.