Evidence map›Paper›PMID 28194614›Full record

ReviewCurrent environmental health reports2017

The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease.

Germaine M Buck Louis, Melissa M Smarr, Chirag J Patel

Abstract readReview
In one paragraph

Review in Current environmental health reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Association of Childhood Asthma with the Concept of Exposomics: A Short Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Geospatial Science for the Environmental Epidemiology of Cancer in the Exposome Era.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The Exposome and Toxicology: A Win-Win Collaboration.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Review
  18. Research on Women's Health: Ready for the Future.Journal of women's health (2002) · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Germaine M Buck LouisOffice of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA. louisg@mail.nih.gov.
Melissa M SmarrOffice of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA.
Chirag J PatelDepartment of Biomedical Informatics, Harvard Medical School, 10 Shattuck St., Boston, MA, 02115, USA.

Funding

TrainingU54HG007963 · NHGRI · HARVARD MEDICAL SCHOOL · PI KOHANE, ISAAC S., MURPHY, SHAWN N · 2014 to 2018
$18.3M
Data-driven identification of environmental factors in cardiovascular diseaseR00ES023504 · NIEHS · HARVARD MEDICAL SCHOOL · PI PATEL, CHIRAG J. · 2016 to 2018
$728k
Increasing the power of GxE detection by using multi-locus genome-wide predictorsR21ES025052 · NIEHS · HARVARD MEDICAL SCHOOL · PI PATEL, CHIRAG J. · 2015 to 2017
$434k
NHGRI NIH HHS U54 HG007963NIEHS NIH HHS R00 ES023504NIEHS NIH HHS R21 ES025052
6 · The paper itself

Abstract

purpose of reviewThis paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan. RECENT

findingsThe exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts. Despite the notable challenges underlying the exposome paradigm, analytic techniques are being developed to handle its untargeted approach and correlated and multi-level or hierarchical data structures such initiatives generate, while considering multiple comparisons. The relatively short intervals for critical and sensitive windows of human reproduction and development seem well suited for exposome research and may revolutionize our understanding of later onset diseases. Early initiatives suggest that the exposome paradigm is feasible, but its utility remains to be established with applications to population human health research.

Indexed as

DiseaseEnvironmental HealthEnvironmental ExposureEnvironmental MonitoringHumansReproductionResearch DesignDesignEpidemiologyExposomeMethodsReproduction

Identifiers

PMID28194614
PMCPMC5363405

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.