Evidence map›Paper›PMID 28194569›Full record

ReviewCurrent atherosclerosis reports2017

The Role of Inflammation in Cardiovascular Outcome.

Fabrizio Montecucco, Luca Liberale, Aldo Bonaventura, Alessandra Vecchiè, Franco Dallegri, Federico Carbone

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fabrizio MontecuccoFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.
Luca LiberaleFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.
Aldo BonaventuraFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.
Alessandra VecchièFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.
Franco DallegriFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.
Federico CarboneFirst Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy. federico.carbone@edu.unige.it.
University of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to update the pathophysiological role of innate immune response in the cardiovascular (CV) disease outcomes, particularly focusing on coronary atherosclerosis and heart failure. RECENT

findingsInflammatory processes comprised with the innate immunity reaction are believed to actively trigger CV disease development and final clinical events. For instance, by releasing proteases and neutrophil extracellular traps, neutrophil recruitment and activation might strongly influence atherosclerotic plaque stability. Similarly, neutrophils drive the early inflammatory response following a myocardial infarction. However, these cells contribute themselves to infarct healing by orchestrating monocyte/macrophage recruitment and polarization within the ischemic myocardium. Given their heterogeneity and plasticity, the balance between recruitment, proliferation, and polarization of monocyte/macrophage is a further leading determinant of advanced plaque maturation. Moreover, timely shift from a pro-inflammatory to a resolving macrophage phenotype may influence cardiac remodeling as well as development of heart failure (HF). Alongside macrophage recruitment and activation into the remote, non-ischemic myocardium also contributes to cardiac remodeling and HF development. Innate immune response is a tightly regulated process where a timely modulation of the balance between damaging and resolving properties critically impacts on CV outcome. Further progress may improve the determination of the prognostic relevance of inflammatory biomarkers on clinical CV outcome.

Indexed as

AnimalsCoronary Artery DiseaseHeartHeart FailureHumansImmunity, InnateInflammationMyocardial InfarctionPlaque, AtheroscleroticAtherosclerosisHeart failureInflammationMacrophageMyocardial infarctionNeutrophil

Identifiers

PMID28194569
OpenAlexW2588414820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.