ArticleJCI insight2017
G
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Genetic variants of calcium and vitamin D metabolism in kidney stone disease.Nature communications · 2019Pooled it
- An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Characterisation of aEndocrine oncology (Bristol, England) · 2025Article
- Monitoring Calcium-Sensing Receptor (CaSR)-Induced Intracellular Calcium Flux Using an Indo-1 Flow Cytometry Assay.Methods in molecular biology (Clifton, N.J.) · 2025Article
- GNA11 Variants Identified in Patients with Hypercalcemia or Hypocalcemia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor.ACS pharmacology & translational science · 2021Review
- Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model.JBMR plus · 2020Article
- Genetics of kidney stone disease.Nature reviews. Urology · 2020Review
- International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function.Pharmacological reviews · 2020Review
- Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1).The Journal of clinical endocrinology and metabolism · 2020Article
- Activating Mutations of the G-protein Subunit α 11 Interdomain Interface Cause Autosomal Dominant Hypocalcemia Type 2.The Journal of clinical endocrinology and metabolism · 2020Article
- Treatment of Autosomal Dominant Hypocalcemia Type 1 With the Calcilytic NPSP795 (SHP635).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.Nature reviews. Endocrinology · 2018Review
- Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway.British journal of pharmacology · 2018Review
- Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.Human molecular genetics · 2018Article
- Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.Vascular pharmacology · 2018Article
- Calcium-sensing receptor (CaSR) promotes development of bone metastasis in renal cell carcinoma.Oncotarget · 2018Article
- A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.Science signaling · 2018Article
- AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.Cell reports · 2018Article
- Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function GαJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Caroline M GorvinAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Fadil M HannanAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Sarah A HowlesAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Valerie N BabinskyAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Sian E PiretAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Angela RogersAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Andrew J FreidinARUK Centre for Osteoarthritis Pathogenesis, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.
Michelle StewartMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
Anju PaudyalMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
Tertius A HoughMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
M Andrew NesbitAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Sara WellsMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
Tonia L VincentARUK Centre for Osteoarthritis Pathogenesis, The Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.
Stephen Dm BrownMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
Roger D CoxMedical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell Institute, Harwell Science and Innovation Campus, United Kingdom.
Rajesh V ThakkerAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBUniversity of Liverpool · GBUniversity of Ulster · GB
Funding
Medical Research Council G1000467Medical Research Council G9825289Medical Research Council MC_U142661184Medical Research Council MC_U142684172Medical Research Council MC_UP_1502/1Medical Research Council MR/K006312/1
Abstract
Heterozygous germline gain-of-function mutations of G-protein subunit α
Indexed as
MutationAnimalsCalciumDisease Models, AnimalGTP-Binding Protein alpha SubunitsHEK293 CellsHumansHypercalciuriaHypocalcemiaHypoparathyroidismMAP Kinase Signaling SystemMiceNaphthalenesParathyroid HormoneReceptors, Calcium-SensingReceptors, G-Protein-CoupledCalciumCASR protein, mouseGNA11 protein, mouseGTP-Binding Protein alpha SubunitsN-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamineNaphthalenesParathyroid HormoneReceptors, Calcium-SensingReceptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.