Evidence map›Paper›PMID 28194433›Full record

ArticleJCI insight2017

Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma.

Sara C Sebag, Olha M Koval, John D Paschke, Christopher J Winters, Omar A Jaffer, Ryszard Dworski, Fayyaz S Sutterwala, Mark E Anderson, Isabella M Grumbach

Abstract read
In one paragraph

Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sara C SebagDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Olha M KovalDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
John D PaschkeDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Christopher J WintersDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Omar A JafferDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Ryszard DworskiDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Fayyaz S SutterwalaDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Mark E AndersonDepartment of Medicine and.
Isabella M GrumbachDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.

Funding

YOHIMBINE AS A MODEL OF ORTHOSTATIC INTOLERANCEM01RR000095 · NCRR · VANDERBILT UNIVERSITY · PI MAY, JAMES M. · 1985 to 2008
$38.3M
Mitochondrial Calmodulin Kinase II in Physiology and DiseaseR01HL070250 · NHLBI · VANDERBILT UNIVERSITY · PI ANDERSON, MARK E · 2002 to 2017
$5.2M
Mitochondrial CaMKII drives smooth muscle migration and neointimal hyperplasiaR01HL108932 · NHLBI · UNIVERSITY OF IOWA · PI GRUMBACH, ISABELLA MARIA · 2012 to 2021
$3.6M
Targeting the NLRP3 inflammasome to limit pathologic sterile inflammationR01AI118719 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI SUTTERWALA, FAYYAZ S. · 2016 to 2020
$2.2M
Oxidized CaMKII in Atrial FibrillationR01HL113001 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2012 to 2016
$1.9M
Oxidant Stress and Allergic AsthmaK23HL080030 · NHLBI · VANDERBILT UNIVERSITY · PI DWORSKI, RYSZARD T · 2006 to 2009
$609k
Targeting the NLRP3 inflammasome to limit pathologic sterile inflammationR56AI118719 · NIAID · UNIVERSITY OF IOWA · PI SUTTERWALA, FAYYAZ S. · 2015 to 2015
$378k
NCRR NIH HHS M01 RR000095NHLBI NIH HHS K23 HL080030NHLBI NIH HHS R01 HL070250NHLBI NIH HHS R01 HL108932NHLBI NIH HHS R01 HL113001NIAID NIH HHS R01 AI118719NIAID NIH HHS R56 AI118719
6 · The paper itself

Abstract

Excessive ROS promote allergic asthma, a condition characterized by airway inflammation, eosinophilic inflammation, and increased airway hyperreactivity (AHR). The mechanisms by which airway ROS are increased and the relationship between increased airway ROS and disease phenotypes are incompletely defined. Mitochondria are an important source of cellular ROS production, and our group discovered that Ca

Indexed as

AnimalsAntioxidantsAspergillus fumigatusAsthmaCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedDisease Models, AnimalGene Expression RegulationHumansMiceMice, TransgenicMitochondriaNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOvalbuminPeptidesAntioxidantsCalcium-Calmodulin-Dependent Protein Kinase Type 2NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseOvalbuminPeptidesReactive Oxygen Species

Identifiers

PMID28194433
PMCPMC5291733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.