ReviewThe journal of venomous animals and toxins including tropical diseases2017
Highlights in the knowledge of brown spider toxins.
Review in The journal of venomous animals and toxins including tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- The Adjuvant Effect of Hyperbaric Oxygenation forMetabolites · 2025Article
- In silico prospection of receptors associated with the biological activity of U1-SCTRX-lg1a: an antimicrobial peptide isolated from the venom ofIn silico pharmacology · 2024Article
- Massive dermal ulcerative lesions because of brown recluse spider bite: a rare case report and review of literature.Journal of surgical case reports · 2023Article
- Article
- Genomics ofPathogens (Basel, Switzerland) · 2023Article
- Acute necrotic arachnidism with necrotising fasciitis and recurrent pneumothorax.BMJ case reports · 2022Article
- Article
- Specificity of Loxosceles α clade phospholipase D enzymes for choline-containing lipids: Role of a conserved aromatic cage.PLoS computational biology · 2022Article
- Toxin-Mediated Myocarditis From a Brown Recluse Spider Bite.JACC. Case reports · 2022Article
- Toxinology in the proteomics era: a review on arachnid venom proteomics.The journal of venomous animals and toxins including tropical diseases · 2022Article
- A Case Report of Brown Recluse Spider Bite.Cureus · 2021Article
- Brown Spiders' Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms.Biomedicines · 2021Article
- Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?The journal of venomous animals and toxins including tropical diseases · 2021Article
- A loxoscelism case received therapeutic apheresis and hyperbaric oxygen therapy.Saudi medical journal · 2020Article
- Spider bites of medical significance in the Mediterranean area: misdiagnosis, clinical features and management.The journal of venomous animals and toxins including tropical diseases · 2020Review
- Biotechnological potential of Phospholipase D forToxicon: X · 2020Review
- Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential.Toxins · 2020Article
- Review
- Article
- Not so Dangerous After All? Venom Composition and Potency of the Pholcid (Daddy Long-Leg) SpiderFrontiers in ecology and evolution · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function. The signs and symptoms observed following a brown spider bite are called loxoscelism. Brown spider venom is a complex mixture of toxins enriched in low molecular mass proteins (4-40 kDa). Characterization of the venom confirmed the presence of three highly expressed protein classes: phospholipases D, metalloproteases (astacins) and insecticidal peptides (knottins). Recently, toxins with low levels of expression have also been found in
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.