Evidence map›Paper›PMID 28194154›Full record

ReviewFrontiers in immunology2017

The Role of CD4+ T Follicular Helper Cells in HIV Infection: From the Germinal Center to the Periphery.

John Patrick Thornhill, Sarah Fidler, Paul Klenerman, John Frater, Chansavath Phetsouphanh

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Protein-dependent CD4iScience · 2026
    Article
  3. Review
  4. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The immune response to SARS-CoV-2 in people with HIV.Cellular & molecular immunology · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Defining T Cell Subsets in Human Tonsils Using ChipCytometry.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John Patrick ThornhillImperial College London , London , UK.
Sarah FidlerImperial College London , London , UK.
Paul KlenermanUniversity of Oxford , Oxford , UK.
John FraterUniversity of Oxford , Oxford , UK.
Chansavath PhetsouphanhUniversity of Oxford , Oxford , UK.

Funding

Medical Research Council MR/L00528X/1Medical Research Council MR/L006588/1Medical Research Council MR/N001265/1Wellcome Trust 109965/Z/15/Z
6 · The paper itself

Abstract

T follicular helper cells (TFh) are key components of the adaptive immune system; they are primarily found in germinal centers (GCs) where their interaction with B cells supports humoral immune responses and efficient antibody production. They are defined by the expression of CXC receptor 5, program death-1, ICOS, and secretion of IL-21. Their differentiation is regulated by B-cell lymphoma 6. The relationship and function of circulating TFh to

Indexed as

HIVreservoirT cellsTfh cellsviral immunity

Identifiers

PMID28194154
PMCPMC5277018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.