Evidence map›Paper›PMID 28194095›Full record

ArticleFrontiers in neuroscience2017

Altered Hippocampo-Cerebello-Cortical Circuit in Schizophrenia by a Spatiotemporal Consistency and Causal Connectivity Analysis.

Xi Chen, Yuchao Jiang, Lin Chen, Hui He, Li Dong, Changyue Hou, Mingjun Duan, Mi Yang, Dezhong Yao, Cheng Luo

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  5. [Illness duration-related developmental trajectory of progressive cerebral gray matter changes in schizophrenia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xi ChenKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Yuchao JiangKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Lin ChenKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Hui HeKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Li DongKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Changyue HouKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Mingjun DuanKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaChengdu, China; Department of Psychiatry, The Fourth People's Hospital ChengduChengdu, China.
Mi YangKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaChengdu, China; Department of Psychiatry, The Fourth People's Hospital ChengduChengdu, China.
Dezhong YaoKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Cheng LuoKey Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the current study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the local consistency by integrating the temporal and spatial information of the local region. In the current study, resting-state fMRI data of 69 schizophrenia patients and 70 healthy controls were collected. FOCA was utilized to investigate the local consistency. Moreover, Granger causal analysis was used to investigate causal functional connectivity among these areas, which exhibited significantly different local consistency between groups. Compared with the healthy controls, the schizophrenia patients exhibited increased local consistency in hippocampus, basal ganglia and cerebellum regions, and decreased local consistency in sensoriperceptual cortex. In addition, altered causal functional connectivity was observed in hippocampo-cerebello-cortical (occipital) circuit. These findings suggested that this circuit might play a role in the motor dysfunction in schizophrenia, and should be paid more attention in future.

Indexed as

Chinese Clinical Trial Registrygranger causal analysishippocampuslocal consistencyRegistration number. ChiCTR-RCS-14004878.resting-state fMRIschizophrenia

Identifiers

PMID28194095
PMCPMC5277003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.