ArticleMolecular psychiatry2018
Genetic contributions to self-reported tiredness.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Interindividual Variability in Mental Fatigue-Related Impairments in Endurance Performance: A Systematic Review and Multiple Meta-regression.Sports medicine - open · 2023Pooled it
- Personality and fatigue: meta-analysis of seven prospective studies.Scientific reports · 2022Pooled it
- Fatigue Among Adults Age 18 and Older: United States, 2024.National health statistics reports · 2026Article
- Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients.Nature communications · 2026Article
- A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Development and validation of the rest experience scale for adults with chronically fatiguing conditions.PloS one · 2026Article
- Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.Journal of the National Cancer Institute · 2025Article
- Mathematical modeling of dopamine rhythms and timing of dopamine reuptake inhibitors.PLoS computational biology · 2025Article
- Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.Psychological medicine · 2025Article
- EBNA-1 and VCA-p18 immunoglobulin markers link Epstein-Barr virus immune response and brain's myelin content to fatigue in a community-dwelling cohort.Brain, behavior, & immunity - health · 2024Article
- Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue.Translational psychiatry · 2024Article
- A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals.Communications biology · 2024Article
- Article
- COLOCdb: a comprehensive resource for multi-model colocalization of complex traits.Nucleic acids research · 2024Article
- Causal associations of fatigue and functional outcome after ischemic stroke: a mediation Mendelian randomization study.Frontiers in neurology · 2024Article
- Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.Osteoarthritis and cartilage open · 2023Article
- ANO10 Function in Health and Disease.Cerebellum (London, England) · 2023Review
- Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits.Nucleic acids research · 2023Article
- Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis.Frontiers in psychiatry · 2023Article
- Exploring causal effects of smoking and alcohol related lifestyle factors on self-report tiredness: A Mendelian randomization study.PloS one · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8.4% (s.e.=0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; P=1.36 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.