Evidence map›Paper›PMID 28193893›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Putative transmembrane transporter modulates higher-level aggression in

Budhaditya Chowdhury, Yick-Bun Chan, Edward A Kravitz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. MasculinizedThe Journal of experimental biology · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Budhaditya ChowdhuryDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Yick-Bun ChanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Edward A KravitzDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115 edward_kravitz@hms.harvard.edu.

Funding

Aggression in Drosophila: circuitry involved; learning and memory accompanying aggression; and establishing the circuitry of high-level aggression in the brainR35GM118137 · NIGMS · HARVARD MEDICAL SCHOOL · PI KRAVITZ, EDWARD A · 2016 to 2022
$4.0M
Hormonal Modulation of Aggression in DrosophilaR01GM074675 · NIGMS · HARVARD MEDICAL SCHOOL · PI KRAVITZ, EDWARD A · 2006 to 2014
$2.6M
How Do Amine Neurons Work - Diversity SupplementR01GM099883 · NIGMS · HARVARD MEDICAL SCHOOL · PI KRAVITZ, EDWARD A · 2012 to 2015
$1.5M
NIGMS NIH HHS R01 GM074675NIGMS NIH HHS R01 GM099883NIGMS NIH HHS R35 GM118137
6 · The paper itself

Abstract

By selection of winners of dyadic fights for 35 generations, we have generated a hyperaggressive Bully line of flies that almost always win fights against the parental wild-type Canton-S stock. Maintenance of the Bully phenotype is temperature dependent during development, with the phenotype lost when flies are reared at 19 °C. No similar effect is seen with the parent line. This difference allowed us to carry out RNA-seq experiments and identify a limited number of genes that are differentially expressed by twofold or greater in the Bullies; one of these was a putative transmembrane transporter,

Indexed as

AggressionAmino Acid Transport SystemsAnimalsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationMaleRNA, MessengerRNA, Small InterferingTemperatureAmino Acid Transport SystemsDrosophila ProteinsRNA, MessengerRNA, Small InterferingaggressionDrosophilatransmembrane neutral amino acid transporter

Identifiers

PMID28193893
PMCPMC5338563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.