Evidence map›Paper›PMID 28193860›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Investigations of human myosin VI targeting using optogenetically controlled cargo loading.

Alexander R French, Tobin R Sosnick, Ronald S Rock

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander R FrenchDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
Tobin R SosnickDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637; trsosnic@uchicago.edu rrock@uchicago.edu.
Ronald S RockDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637; trsosnic@uchicago.edu rrock@uchicago.edu.
University of Chicago · US

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Kinetic studies of protein foldingR01GM055694 · NIGMS · UNIVERSITY OF CHICAGO · PI SOSNICK, TOBIN R · 2001 to 2022
$7.6M
Allostery in myosins studied at the molecular levelR01GM078450 · NIGMS · UNIVERSITY OF CHICAGO · PI ROCK, RONALD S · 2006 to 2015
$2.8M
Force-sensitive macromolecular cytoskeletal assemblyR01GM109863 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N, ROCK, RONALD S · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM055694NIGMS NIH HHS R01 GM078450NIGMS NIH HHS R01 GM109863NIGMS NIH HHS T32 GM007183
6 · The paper itself

Abstract

Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive

Indexed as

ActinsCell Line, TumorHeLa CellsHumansMyosin Heavy ChainsOptogeneticsSecond Messenger SystemsActinsMyosin Heavy Chainsmyosin VILOV2motor proteinsmyosin VIoptogeneticsprotein regulation

Identifiers

PMID28193860
PMCPMC5338553
OpenAlexW2949191091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.