Evidence map›Paper›PMID 28193855›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

BMP signaling controls buckling forces to modulate looping morphogenesis of the gut.

Nandan L Nerurkar, L Mahadevan, Clifford J Tabin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Article
  3. A model for boundary-driven tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025
    Review
  7. Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  8. Article
  9. Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024
    Review
  10. The developmental mechanics of divergent buckling patterns in the chick gut.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Review
  20. The Development of the Mesenteric Model of Abdominal Anatomy.Clinics in colon and rectal surgery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nandan L NerurkarDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
L MahadevanSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; tabin@genetics.med.harvard.edu lm@seas.harvard.edu.
Clifford J TabinDepartment of Genetics, Harvard Medical School, Boston, MA 02115; tabin@genetics.med.harvard.edu lm@seas.harvard.edu.
Harvard University · US

Funding

Signals and mechanical forces controlling radial gut morphogenesisR01HD087234 · NICHD · HARVARD MEDICAL SCHOOL · PI TABIN, CLIFFORD J. · 2016 to 2025
$3.2M
Mechanical and molecular factors underlying morphogenesis of the intestinal villiF32HD069074 · NICHD · HARVARD MEDICAL SCHOOL · PI NERURKAR, NANDAN L · 2011 to 2013
$148k
NICHD NIH HHS F32 HD069074NICHD NIH HHS R01 HD087234
6 · The paper itself

Abstract

Looping of the initially straight embryonic gut tube is an essential aspect of intestinal morphogenesis, permitting proper placement of the lengthy small intestine within the confines of the body cavity. The formation of intestinal loops is highly stereotyped within a given species and results from differential-growth-driven mechanical buckling of the gut tube as it elongates against the constraint of a thin, elastic membranous tissue, the dorsal mesentery. Although the physics of this process has been studied, the underlying biology has not. Here, we show that BMP signaling plays a critical role in looping morphogenesis of the avian small intestine. We first exploited differences between chicken and zebra finch gut morphology to identify the BMP pathway as a promising candidate to regulate differential growth in the gut. Next, focusing on the developing chick small intestine, we determined that

Indexed as

Gene Expression Regulation, DevelopmentalMechanotransduction, CellularAnimalsAvian ProteinsBiomechanical PhenomenaBone Morphogenetic Protein 2Carrier ProteinsChick EmbryoChickensFinchesGenes, ReporterGenetic VectorsGreen Fluorescent ProteinsIntestine, SmallMesenteryMorphogenesisAvian ProteinsBone Morphogenetic Protein 2Carrier ProteinsGreen Fluorescent ProteinsNoggin ProteinbiomechanicsBmpbucklingintestinal loopingmorphogenesis

Identifiers

PMID28193855
PMCPMC5338480
OpenAlexW2587867535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.