Evidence map›Paper›PMID 28193847›Full record

ArticleMolecular and cellular biology2017

DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability.

Zhiguo Li, Chen Shao, Yifan Kong, Colin Carlock, Nihal Ahmad, Xiaoqi Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. PLK1 phosphorylates WRN at replication forks.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  2. Review
  3. Article
  4. MDC1 is essential for G2/M transition and spindle assembly in mouse oocytes.Cellular and molecular life sciences : CMLS · 2022
    Article
  5. Oncology letters · 2020
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhiguo LiDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Chen ShaoDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Yifan KongDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Colin CarlockDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA.
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
Xiaoqi LiuDepartment of Biochemistry, Purdue University, West Lafayette, Indiana, USA liu8@purdue.edu.
Purdue University West Lafayette · USCenter for Cancer Research · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Role of Polo-Like Kinase-1 in Melanocytic TransformationR01AR059130 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2010 to 2019
$3.8M
Plk1 in Chemo-resistance of CancerR01CA157429 · NCI · UNIVERSITY OF KENTUCKY · PI XIAOQI LIU · 2011 to 2026
$3.5M
Improving chemotherapy of castration-resistant prostate cancer.R01CA196634 · NCI · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI · 2016 to 2025
$3.3M
Treatment of Castration-resistant Prostate Cancer (CRPC)R01CA196835 · NCI · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI · 2016 to 2020
$1.7M
Enhancing anti-neoplastic activity of metformin in prostate cancerR01CA192894 · NCI · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI · 2016 to 2020
$1.7M
Role of SIRT1 in melanocyte biology and melanocyte transformationR01CA176748 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2013 to 2017
$1.6M
BD Fortessa Flow Cytometer for Multi-User Shared FacilityS10OD020029 · OD · PURDUE UNIVERSITY · PI RATLIFF, TIMOTHY L. · 2015 to 2015
$412k
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA157429NCI NIH HHS R01 CA176748NCI NIH HHS R01 CA192894NCI NIH HHS R01 CA196634NCI NIH HHS R01 CA196835NIAMS NIH HHS R01 AR059130NIH HHS S10 OD020029
6 · The paper itself

Abstract

MDC1 is a central player in checkpoint activation and subsequent DNA repair following DNA damage. Although MDC1 has been studied extensively, many of its known functions, to date, pertain to the DNA damage response (DDR) pathway. Herein we report a novel function of phosphorylated MDC1 that is independent of ATM and DNA damage and is required for proper mitotic progression and maintenance of genomic stability. We demonstrate that MDC1 is an

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle CheckpointsCell Cycle ProteinsCell Line, TumorCell ProliferationCell Transformation, NeoplasticChromosomal InstabilityDNA DamageDNA RepairHeLa CellsHistonesHumansIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutAdaptor Proteins, Signal TransducingCell Cycle Proteinsgamma-H2AX protein, mouseHistonesIntracellular Signaling Peptides and ProteinsMDC1 protein, mousePolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsRNA, Small Interferinggenomic instabilityMDC1mitosisphosphorylationPlk1

Identifiers

PMID28193847
PMCPMC5394279
OpenAlexW2588101855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.