Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

1. Effects of Nutrition Education Program for the Japan Diet on Serum Phospholipid Fatty Acid Compositions in Patients with Dyslipidemia: Re-analysis of Data from a Previous Randomized Controlled Trial.Journal of atherosclerosis and thrombosis · 2023
   Trial
2. The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells.eLife · 2025
   Article
3. GαJournal of the Endocrine Society · 2024
   Article
4. The prostaglandin EAmerican journal of physiology. Endocrinology and metabolism · 2024
   Article
5. EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.Islets · 2023
   Article
6. Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort.The Journal of pharmacology and experimental therapeutics · 2023
   Observational
7. What the BTBR/J mouse has taught us about diabetes and diabetic complications.iScience · 2023
   Review
8. Noncanonical Regulation of cAMP-Dependent Insulin Secretion and Its Implications in Type 2 Diabetes.Comprehensive Physiology · 2023
   Article
9. Plasma Prostaglandin EMetabolites · 2022
   Article
10. Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis.Cell & bioscience · 2022
    Article
11. Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes.International journal of molecular sciences · 2022
    Review
12. Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.Metabolites · 2022
    Review
13. mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1.Nature metabolism · 2022
    Article
14. Pharmacological blockade of the EP3 prostaglandin EMolecular metabolism · 2021
    Article
15. β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications.International journal of molecular sciences · 2021
    Review
16. Prostaglandin EP3 receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance.American journal of physiology. Endocrinology and metabolism · 2021
    Article
17. Human Islet Expression Levels of Prostaglandin EACS pharmacology & translational science · 2021
    Article
18. Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.Pharmacology research & perspectives · 2021
    Article
19. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin EMetabolites · 2021
    Article
20. Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders.Frontiers in physiology · 2021
    Review

Corrections and comments

• Commented on by
  The COX-2/PGE2017

Authors and funding

14 authors at 1 institution in 1 country.

Funding

Abstract

Indexed as