Evidence map›Paper›PMID 28193784›Full record

ArticlePhysiological reports2017

Impaired myogenic response of the afferent arteriole contributes to the increased susceptibility to renal disease in Milan normotensive rats.

Ying Ge, Fan Fan, Sean P Didion, Richard J Roman

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Animal models of hypertension and concurrent organs injury.Animal models and experimental medicine · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology.American journal of physiology. Renal physiology · 2021
    Article
  8. A Mutation inJournal of the American Society of Nephrology : JASN · 2020
    Article
  9. Review
  10. Observational
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ying GeDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Fan FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Sean P DidionDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi rroman@umc.edu.
University of Mississippi Medical Center · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Renal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8M
Animal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419k
NIA NIH HHS R21 AG050049NIDDK NIH HHS R01 DK104184NIGMS NIH HHS P20 GM104357
6 · The paper itself

Abstract

Milan normotensive (MNS) rats are more susceptible to the development of renal disease than Milan hypertensive (MHS) rats, but the genes and pathways involved are unknown. This study compared the myogenic response of isolated perfused afferent arterioles (Af-Art) and autoregulation of renal blood flow (RBF) and glomerular capillary pressure (Pgc) in 6-9-week-old MNS and MHS rats. The diameter of the Af-Art of MHS rats decreased significantly from 14.3 ± 0.5 to 11.5 ± 0.6

Indexed as

HomeostasisAnimalsArteriolesDiabetes Mellitus, ExperimentalDisease Models, AnimalHypertensionKidneyKidney DiseasesMaleProteinuriaRatsChronic kidney diseasediabetic nephropathyglomerulusrenal hemodynamics

Identifiers

PMID28193784
PMCPMC5309574
OpenAlexW2588540579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.